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Acid phosphatase (prostatic)

Acid phosphatase (prostatic)

Prostatic Acid Phosphatase (PAP) is an enzyme primarily produced by the prostate gland, historically significant as a tumor marker for prostate cancer. Although its role in screening has diminished with the advent of prostate-specific antigen (PSA) testing, PAP remains useful in specific clinical scenarios. It can provide prognostic information for predicting recurrence after radical prostatectomy and monitoring treatment responses, particularly in cases where PSA results are inconclusive. However, elevated PAP levels can also result from benign conditions like benign prostatic hyperplasia or prostatic infarction, complicating interpretation. The test involves an automated chemiluminescent immunometric assay, requiring careful specimen collection and processing to ensure accuracy. While PAP offers supplementary insights, it should be interpreted alongside other diagnostic tools due to its limited specificity. Despite its reduced role in routine screening, PAP continues to be a valuable adjunct in managing prostate cancer, offering unique insights in certain clinical contexts.

Price of test:£55

The lowest price from the last 30 days: £55

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Prostatic acid phosphatase (PAP) is a glycoprotein enzyme primarily produced by the prostate gland. Historically significant as a tumor marker for prostate cancer, its role has diminished with the advent of PSA testing. However, PAP remains useful in specific scenarios:

- Predicting recurrence post-radical prostatectomy
- Monitoring treatment response, especially in androgen ablation therapy

Limitations include:

- Elevated levels due to benign conditions
- Interference from antibodies

Specimen handling is crucial, requiring immediate freezing for stability. PAP levels should be interpreted alongside other diagnostic tools, offering supplementary insights in prostate cancer management.

Who Should Get Tested

Prostatic acid phosphatase (PAP) testing is primarily relevant for specific clinical scenarios in prostate cancer management. Key considerations include:

- Predicting Recurrence: Useful after radical prostatectomy to assess recurrence risk.
- Monitoring Treatment: Offers supplementary insights during androgen ablation therapy, especially when PSA levels are inconclusive.
- Limitations: Elevated PAP can result from non-cancerous conditions like benign prostatic hyperplasia, complicating interpretation.
- Specimen Handling: Requires careful collection and freezing to ensure accuracy.

While not suitable for routine screening, PAP can provide valuable prognostic information when used alongside other diagnostic tools.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for Prostatic Acid Phosphatase (PAP) involves recognizing its role and limitations in prostate health diagnostics. Here are key points to consider:

- Historical Context: Once a primary marker for prostate cancer, PAP's role has diminished with the advent of PSA testing.
- Current Use: Primarily used for predicting recurrence post-prostatectomy and monitoring treatment, especially when PSA results are inconclusive.
- Limitations: Elevated PAP can result from non-cancerous conditions, complicating interpretation.
- Specimen Handling: Proper collection and storage are crucial for accurate results.
- Clinical Interpretation: PAP should be used alongside other diagnostic tools for comprehensive assessment.

Price of test:£55

The lowest price from the last 30 days: £55

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