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Activated Protein C Resistance

Activated Protein C Resistance

The Activated Protein C (APC) resistance test is a vital laboratory assessment used to evaluate the body's response to activated protein C, a natural anticoagulant crucial for regulating blood coagulation. This test is essential for diagnosing and managing conditions with an elevated risk of venous thromboembolism (VTE), such as deep vein thrombosis (DVT) and pulmonary embolism (PE). APC functions by degrading factors Va and VIIIa, preventing excessive clotting. Resistance to APC, either hereditary or acquired, can lead to increased thrombosis risk. The test involves a modified activated partial thromboplastin time (aPTT) procedure, measuring the clotting time with and without added APC to calculate the APC resistance ratio. A normal ratio ranges from 2.3 to 4.0, with lower values indicating potential hereditary resistance, often linked to the factor V Leiden mutation. The test aids in risk assessment, therapeutic monitoring, and management of thrombotic disorders, despite potential interferences from anticoagulants and technical challenges.

Price of test:£115

The lowest price from the last 30 days: £115

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Activated Protein C (APC) resistance testing evaluates the body's response to APC, a natural anticoagulant. This test is vital for diagnosing conditions with increased venous thromboembolism (VTE) risk, such as deep vein thrombosis (DVT) and pulmonary embolism (PE).

- Test Process:
- Blood collection with sodium citrate.
- Plasma separation and aPTT test.
- APC addition and ratio calculation.

- Result Interpretation:
- Normal ratio: 2.3 to 4.0.
- Abnormal ratio: Indicates hereditary or acquired resistance.

- Clinical Significance:
- Assesses VTE risk.
- Monitors anticoagulant therapy effectiveness.

Who Should Get Tested

The activated protein C resistance test is essential for diagnosing and managing conditions with a heightened risk of venous thromboembolism (VTE). Individuals who should be tested include:

- Those with a family history of VTE.
- Patients with recurrent VTE episodes.
- Individuals with unexplained thrombotic events.

The test evaluates the body's response to activated protein C, a natural anticoagulant. It helps identify hereditary or acquired resistance, guiding treatment decisions. Understanding the test's limitations, such as interference from anticoagulants, is crucial for accurate results and effective management of thrombotic disorders.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for Activated Protein C (APC) resistance is crucial in diagnosing conditions like venous thromboembolism (VTE). Here's a brief guide:

- Normal Ratio: Typically ranges from 2.3 to 4.0. A ratio below 2.3 suggests hereditary APC resistance.
- Abnormal Ratio: Indicates potential hereditary resistance; further DNA testing for factor V Leiden mutation may be needed.
- Clinical Correlation: Results should align with clinical findings, especially in individuals with a family history of VTE or recurrent VTE episodes.

Understanding these results aids in effective risk assessment and management of thrombotic disorders.

Price of test:£115

The lowest price from the last 30 days: £115

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