Anti CENP

The lab test for anti-CENP antibodies is a vital diagnostic tool for detecting autoantibodies against centromere proteins, specifically CENP-A and CENP-B. These antibodies are predominantly found in patients with systemic sclerosis (SSc), an autoimmune disease marked by skin and organ fibrosis. The test aids in diagnosing and classifying SSc, particularly distinguishing between limited cutaneous (lcSSc) and diffuse cutaneous (dcSSc) subtypes. It also evaluates patients with systemic autoimmune rheumatic diseases like Sjogren's syndrome and rheumatoid arthritis. Typically conducted via enzyme-linked immunosorbent assay (ELISA) or multiplex bead assay, the test identifies IgG antibodies against CENP proteins. Clinically, anti-CENP antibodies are more common in lcSSc and are linked to specific clinical profiles, including a lower risk of cardiac and renal issues but a higher risk of pulmonary arterial hypertension. While indicative of SSc, negative results don't exclude the disease, necessitating a comprehensive diagnostic approach.

Price of test:£104

The lowest price from the last 30 days: £104

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The lab test for anti-CENP antibodies is a diagnostic tool for detecting autoantibodies against centromere proteins, aiding in systemic sclerosis (SSc) diagnosis. Key points include:

- Purpose: Distinguishes between limited (lcSSc) and diffuse cutaneous (dcSSc) subtypes; evaluates systemic autoimmune diseases.
- Methodology: Utilizes ELISA or multiplex bead assays to detect IgG antibodies.
- Clinical Significance: Anti-CENP antibodies are more common in lcSSc, indicating specific clinical profiles.
- Predictive Value: Associated with lower cardiac/renal risk but higher pulmonary arterial hypertension risk.
- Diagnostic Utility: Essential for SSc diagnosis, though negative results don't rule out the disease.

Who Should Get Tested

The lab test for anti-CENP antibodies is essential for diagnosing systemic sclerosis (SSc) and distinguishing its subtypes. Key points include:

- Purpose: Identifies autoantibodies against centromere proteins, aiding in SSc diagnosis.
- Methodology: Utilizes ELISA or multiplex bead assays to detect IgG antibodies.
- Clinical Significance: Anti-CENP antibodies are prevalent in limited cutaneous SSc (lcSSc).
- Associations: Linked with other autoantibodies like anti-Scl70.
- Predictive Value: Indicates lower cardiac/renal risk but higher pulmonary arterial hypertension risk.
- Utility: Essential for comprehensive SSc diagnosis and prognosis.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for anti-CENP antibodies involves interpreting their presence and clinical implications. Key points include:

- Purpose: Primarily aids in diagnosing systemic sclerosis (SSc), distinguishing between limited (lcSSc) and diffuse (dcSSc) subtypes.
- Methodology: Utilizes ELISA or multiplex bead assays to detect IgG antibodies against CENP-A and CENP-B.
- Clinical Significance: Anti-CENP antibodies are more common in lcSSc and can predict specific clinical outcomes.
- Diagnostic Utility: Positive results suggest SSc, but negative results don't exclude it; comprehensive evaluation is essential.

Price of test:£104

The lowest price from the last 30 days: £104

AI-Powered Insights and Expert Validation

Advanced AI Interpretation

Diagu's AI system represents a breakthrough in medical test analysis, employing state-of-the-art algorithms meticulously trained on a vast spectrum of authoritative medical literature and data. This system intricately analyses laboratory test results, extracting nuanced insights that might elude conventional methods. Our AI delves into complex interrelations between various health markers, offering a comprehensive understanding that supports accurate diagnosis and effective treatment planning. The foundation of our AI's analytical prowess lies in its extensive training, encompassing data from globally recognised medical journals, trusted healthcare databases, and breakthrough scientific studies. This ensures that every analysis is grounded in the latest and most comprehensive medical knowledge.

Expert Doctor Confirmation

While our AI provides deep analytical insights, the human touch remains indispensable. Every AI-generated interpretation is meticulously reviewed by experienced medical professionals, ensuring a harmonious blend of advanced technology and expert clinical judgment. This dual-layer approach guarantees that the insights provided are not only technologically sophisticated but also clinically relevant. Our medical experts ensure that the AI's interpretations align with current medical standards and practices, adding a layer of validation that only seasoned healthcare professionals can provide. This process reinforces the reliability of the test results, offering peace of mind to both patients and healthcare providers.

Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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