The Anti-Jo-1 blood test detects autoantibodies against Jo-1, a form of histidyl-tRNA synthetase, which is involved in protein synthesis. These autoantibodies are strongly associated with idiopathic inflammatory myopathies, particularly polymyositis, dermatomyositis, and anti-synthetase syndrome—a condition often accompanied by interstitial lung disease, arthritis, Raynaud’s phenomenon, and fever.
Anti-Jo-1 antibodies are present in approximately 20–30% of patients with polymyositis and in up to 60–70% of those with interstitial lung disease associated with inflammatory myopathies. Their presence is often linked with more severe and systemic disease and can guide both diagnosis and prognosis.
More
The Anti-Jo-1 blood test detects autoantibodies against Jo-1, a form of histidyl-tRNA synthetase, which is involved in protein synthesis. These autoantibodies are strongly associated with idiopathic inflammatory myopathies, particularly polymyositis, dermatomyositis, and anti-synthetase syndrome—a condition often accompanied by interstitial lung disease, arthritis, Raynaud’s phenomenon, and fever.
Anti-Jo-1 antibodies are present in approximately 20–30% of patients with polymyositis and in up to 60–70% of those with interstitial lung disease associated with inflammatory myopathies. Their presence is often linked with more severe and systemic disease and can guide both diagnosis and prognosis.
Price of test:£120
The lowest price from the last 30 days: £120
Awaiting result:
12 hours
Collect material:
Blood
Prepare:
Learn more
Purpose of the test
The test is used to:
Diagnose autoimmune muscle disorders such as polymyositis and dermatomyositis
Detect anti-synthetase syndrome and assess the risk of interstitial lung disease
Support differential diagnosis in patients with unexplained muscle weakness, lung involvement, or arthritis
Guide treatment planning and disease monitoring in inflammatory myopathies
Who Should Get Tested
This test is recommended for:
Patients with unexplained proximal muscle weakness or elevated muscle enzymes (e.g., CK)
Individuals with suspected polymyositis or dermatomyositis
Patients presenting with signs of interstitial lung disease in the context of autoimmune symptoms
Those evaluated for anti-synthetase syndrome with symptoms such as arthritis, Raynaud’s, or mechanic’s hands
Blood Test Preparation Guidelines
Time of day
It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.
Fasting
It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.
Stay hydrated
Drinking water prior to testing can help with sample collection.
Other factors
Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.
Medications and supplements:
Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.
Biotin supplements:
High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.
Interpreting Test Results
Positive Anti-Jo-1: Indicates high likelihood of inflammatory myopathy, especially with lung involvement
Negative: Does not exclude myositis, as other autoantibodies may be involved
Positive results may correlate with:
Anti-synthetase syndrome
Polymyositis or dermatomyositis
Interstitial lung disease with autoimmune features
Results should be interpreted in combination with clinical findings, imaging, and muscle enzyme levels
Price of test:£120
The lowest price from the last 30 days: £120
AI-Powered Insights and Expert Validation
Advanced AI Interpretation
Diagu's AI system represents a breakthrough in medical test analysis, employing state-of-the-art algorithms meticulously trained on a vast spectrum of authoritative medical literature and data. This system intricately analyses laboratory test results, extracting nuanced insights that might elude conventional methods. Our AI delves into complex interrelations between various health markers, offering a comprehensive understanding that supports accurate diagnosis and effective treatment planning. The foundation of our AI's analytical prowess lies in its extensive training, encompassing data from globally recognised medical journals, trusted healthcare databases, and breakthrough scientific studies. This ensures that every analysis is grounded in the latest and most comprehensive medical knowledge.
Expert Doctor Confirmation
While our AI provides deep analytical insights, the human touch remains indispensable. Every AI-generated interpretation is meticulously reviewed by experienced medical professionals, ensuring a harmonious blend of advanced technology and expert clinical judgment. This dual-layer approach guarantees that the insights provided are not only technologically sophisticated but also clinically relevant. Our medical experts ensure that the AI's interpretations align with current medical standards and practices, adding a layer of validation that only seasoned healthcare professionals can provide. This process reinforces the reliability of the test results, offering peace of mind to both patients and healthcare providers.
Language Model and Trusted Sources
At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.
FAQ
Answers to Common Questions
What is GetLabTest.com?
How do I get started with GetLabTest.com?
What diseases can GetLabTest.com detect?
How do I prepare for testing with GetLabTest.com?
Can I speak with a doctor about my results?
Is testing with GetLabTest.com covered by insurance?
How long does it take to receive the test results?
Can I access my test results online?
Is my personal information kept confidential?
What if I have questions or concerns about my test results?
