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Apolipoprotein E

Apolipoprotein E

Apolipoprotein E (APOE) genotyping is a genetic test that identifies specific alleles of the APOE gene, crucial in lipid metabolism and linked to cardiovascular and neurological disorders. The test focuses on detecting the e2, e3, and e4 alleles. Its primary purpose is to assess the risk of Alzheimer's disease and type III hyperlipoproteinemia. The presence of the e4 allele indicates a higher risk for Alzheimer's, though it does not cause the disease. For type III hyperlipoproteinemia, the test aids in diagnosing familial dysbetalipoproteinemia, marked by elevated cholesterol and triglycerides. The test employs molecular genetics techniques like Sanger sequencing or PCR to identify APOE alleles. While it provides predictive risk information, it should be interpreted alongside clinical findings and family history. Informed consent and genetic counseling are recommended due to the test's implications. Despite limitations, APOE genotyping is a valuable tool in clinical practice.

Price of test:£140

The lowest price from the last 30 days: £140

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

APOE genotyping is a clinical test to detect alleles e2, e3, and e4 of the APOE gene, crucial for lipid metabolism. Its primary purpose is to assess disease risk, particularly Alzheimer's and type III hyperlipoproteinemia. Key points include:

- Methodology: Uses Sanger Sequence Analysis or PCR for allele identification.
- Clinical Utility: Offers predictive risk information, aiding diagnosis and treatment.
- Interpretation: Results should be contextualized with clinical data.
- Specimen Requirements: 3 mL of whole blood in EDTA tube.
- Limitations: Cannot predict Alzheimer's or detect all hyperlipoproteinemia variants.

Who Should Get Tested

APOE genotyping is crucial for assessing disease risk, particularly Alzheimer's and type III hyperlipoproteinemia. Key points include:

- Purpose: Identifies e2, e3, e4 alleles to assess disease risk.
- Methodology: Uses Sanger sequencing or PCR for allele detection.
- Clinical Utility: Offers predictive risk information; supports diagnosis.
- Interpretation: e4 allele increases Alzheimer's risk but isn't definitive.
- Specimen: Requires 3 mL blood in EDTA tube; no freezing.
- Consent: Informed consent and counseling are essential.
- Limitations: Doesn't detect all variants; careful interpretation needed.

Overall, APOE genotyping provides valuable insights but requires careful consideration and counseling.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for APOE genotyping involves several key points:

- Risk Assessment: Identifies risk for Alzheimer's and type III hyperlipoproteinemia.
- Allele Identification: Focuses on e2, e3, and e4 alleles.
- Interpretation: Presence of e4 increases Alzheimer's risk but doesn't guarantee it.
- Clinical Context: Results should be considered with clinical findings and family history.
- Limitations: Cannot predict or rule out disease development; rare variants may affect accuracy.
- Counseling: Informed consent and genetic counseling are recommended for understanding implications.

Price of test:£140

The lowest price from the last 30 days: £140

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