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Apolipoprotein E Genotype

Apolipoprotein E Genotype

Apolipoprotein E (APOE) genotyping is a laboratory test that identifies specific genotypes of the APOE gene in an individual's DNA, crucial for assessing risks of diseases like Alzheimer's and type III hyperlipoproteinemia. Located on chromosome 19, the APOE gene encodes three main isoforms: E2, E3, and E4. The test primarily aims to identify APOE alleles (e2, e3, e4) to aid in clinical applications. It is particularly useful for diagnosing type III hyperlipoproteinemia, associated with the e2 allele, and assessing Alzheimer's risk, linked to the e4 allele. The test employs polymerase chain reaction (PCR) with restriction digestion to distinguish alleles, requiring a whole blood specimen. Results should be interpreted alongside clinical findings and family history. While not recommended for predictive Alzheimer's testing due to limited utility, APOE genotyping remains a valuable tool when combined with other diagnostic methods, providing insights into genetic predispositions and supporting clinical diagnoses.

Price of test:£407

The lowest price from the last 30 days: £407

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

APOE genotyping is a vital test for identifying specific APOE alleles (e2, e3, e4) in DNA, aiding in disease risk assessment. Key applications include:

- Type III Hyperlipoproteinemia: Identifies the e2 allele, aiding diagnosis and management.
- Alzheimer's Disease Risk: Provides risk information, especially regarding the e4 allele, though not recommended for predictive testing.
- Clinical Diagnosis: Supports Alzheimer's diagnosis in symptomatic individuals.

The test uses PCR and requires a whole blood specimen. Results must be interpreted alongside clinical data. Limitations include potential false results and limited predictive value for Alzheimer's. Informed consent is essential.

Who Should Get Tested

APOE genotyping is essential for assessing disease risk, particularly Alzheimer's and type III hyperlipoproteinemia. Key points include:

- Type III Hyperlipoproteinemia: Identifies the e2 allele, aiding diagnosis and management.
- Alzheimer's Risk: The e4 allele indicates increased risk, though predictive value is limited.
- Clinical Diagnosis: Supports Alzheimer's diagnosis alongside other tools.

The test uses PCR to identify APOE alleles from a blood specimen. Results must be interpreted with clinical context. Limitations include:

- Predictive Value: Not recommended for Alzheimer's prediction.
- False Results: Possible due to rare variants.

Informed consent is necessary, and specimens must be handled properly for accurate results.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results from APOE genotyping is crucial for assessing genetic risk factors. Here's a concise guide:

- Type III Hyperlipoproteinemia: Identifying the e2 allele aids in diagnosing this condition, characterized by high cholesterol and triglycerides.

- Alzheimer's Disease Risk: The e4 allele indicates increased risk, but the test is not recommended for predictive purposes due to limited utility.

- Clinical Diagnosis: Supports Alzheimer's diagnosis in symptomatic individuals alongside other tools.

- Interpretation: Results should be considered with clinical findings and family history.

- Limitations: Not definitive for Alzheimer's prediction; false results possible.

Understanding these aspects ensures informed healthcare decisions.

Price of test:£407

The lowest price from the last 30 days: £407

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