AST/GOT

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The Aspartate Aminotransferase (AST) test is a blood test that measures the level of AST in the blood. AST is an enzyme found in various tissues throughout the body, but it is most commonly associated with the liver and heart. The test is used to evaluate liver function and to diagnose and monitor liver disease and other conditions that affect the liver or other organs that contain AST. The test is also sometimes used to monitor treatment of certain conditions or to assess the risk of complications during surgery. The AST test is a simple and relatively non-invasive procedure that involves drawing a small amount of blood from an arm vein. Results are usually available within a few days and are reported in units per liter (U/L) or international units per liter (IU/L).

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The aspartate aminotransferase (AST) test is a valuable tool for diagnosing and monitoring liver disease and other conditions that affect the liver or other organs that contain AST. The test measures the level of AST in the bloodstream, which may indicate liver damage or disease. Some of the possible reasons for performing the AST test include

- Diagnosing liver disease: The AST test is often used to diagnose liver disease, such as hepatitis, cirrhosis, or fatty liver disease. Elevated levels of AST in the blood may indicate liver damage or inflammation.

- Monitoring treatment: The AST test may also be used to monitor treatment for liver disease or other conditions that affect the liver. Regular testing can help doctors determine if treatment is working and make adjustments as needed.

- Assessing risk before surgery: The AST test can be used to assess a patient's risk of complications during surgery. Elevated levels of AST may indicate an increased risk of bleeding or other complications.

- Assessing heart health: While the AST test is primarily associated with liver function, it can also be used to assess heart health. Elevated levels of AST combined with elevated levels of another enzyme called creatine kinase (CK) can indicate a heart attack.

Early detection is key to the management and treatment of many health conditions, including those that affect the liver. The AST test can help detect liver damage or disease early, before symptoms become severe. This allows doctors to intervene early and prevent further damage to the liver.

On the other hand, not getting the AST test when it is recommended can have serious consequences. Liver disease can progress quickly and cause irreversible damage if left untreated. In some cases, it can even lead to life-threatening complications such as cirrhosis or liver failure.

An aspartate aminotransferase (AST) blood test is important for diagnosing and monitoring liver disease, assessing risk before surgery, and evaluating heart health. Early detection is key to the management and treatment of many health conditions, including those that affect the liver. Failure to take the test when recommended can have serious consequences, including irreversible liver damage or life-threatening complications.

Who Should Get Tested

Aspartate aminotransferase (AST) testing may be recommended for people who are at risk for liver disease or other conditions that affect the liver. Some of the groups of people who may benefit from AST testing include

- People with a family history of liver disease: If you have a family history of liver disease, your doctor may recommend AST testing to help assess your risk.

- People with obesity or diabetes: Both obesity and diabetes are risk factors for liver disease. If you have either of these conditions, your doctor may recommend regular AST testing to monitor your liver function.

- People who drink alcohol excessively: Excessive alcohol consumption can cause liver damage and increase the risk of liver disease. If you drink heavily, your doctor may recommend AST testing to monitor your liver function.

- People who have been exposed to hepatitis: If you have been exposed to the hepatitis virus, your doctor may recommend AST testing to assess your risk of developing hepatitis or other liver disease.

- People taking medications that can damage the liver: Certain medicines can cause liver damage or inflammation. If you are taking medications known to affect the liver, your doctor may recommend regular AST testing to monitor your liver function.

Note that not everyone in these groups needs an AST test. Your doctor will consider your individual health history and other factors before recommending any tests or treatments.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Results of an aspartate aminotransferase (AST) blood test are usually reported in units per liter (U/L) or international units per liter (IU/L). The normal range for AST levels can vary depending on the laboratory that analyzed the sample, so it is important to look at the reference range provided on your test report. In general, normal AST levels are

- For men: 10-40 U/L
- For women: 9-32 U/L

Elevated AST levels may indicate liver damage or disease, but may also be caused by other factors such as muscle injury or certain medications. The severity of the elevation can provide additional information about the extent of liver damage. For example:

- Mild elevation: 2-3 times the upper limit of normal
- Moderate elevation: 4-6 times the upper limit of normal
- Severe elevation: More than 10 times the upper limit of normal

Be aware that elevated AST levels do not necessarily mean that you have liver disease. Additional testing and evaluation may be needed to determine the cause of elevated AST levels and to develop an appropriate treatment plan.

Interpreting aspartate aminotransferase (AST) blood test results involves looking at the reference range provided on your test report and comparing your results to that range. Elevated AST levels may indicate liver damage or disease, but additional testing and evaluation may be needed to determine the cause and develop a treatment plan.

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