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The Bence Jones protein test is a diagnostic procedure used to identify and measure abnormal light chain proteins in urine, which are typically absent in healthy individuals. These proteins, part of the immune system's antibodies, can indicate systemic diseases like multiple myeloma, a blood cancer. Bence Jones proteins are monoclonal, produced by a single clone of plasma cells. The test involves collecting a urine sample, either a single or 24-hour collection, using a clean-catch method to avoid contamination. Laboratory analysis methods include urine immunofixation electrophoresis, free light chain assay, and urine protein electrophoresis. The presence of Bence Jones proteins often suggests multiple myeloma but can also indicate conditions like monoclonal gammopathy of undetermined significance (MGUS), amyloidosis, or lymphatic system cancers. A normal test result shows no Bence Jones proteins, while their presence necessitates further investigation. The test is safe, involves normal urination, and is crucial for diagnosing and monitoring plasma cell disorders.

Price of test:£34

The lowest price from the last 30 days: £34

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Bence Jones protein test is a diagnostic tool used to detect abnormal proteins in urine, often indicating systemic diseases like multiple myeloma. These proteins, part of antibodies, are not typically found in healthy urine. The test involves:

- Collecting a urine sample, either single or 24-hour, using a clean-catch method.
- Analyzing the sample through methods like Urine Immunofixation Electrophoresis or Free Light Chain Assay.

Presence of Bence Jones proteins suggests conditions such as:

- Multiple Myeloma
- Monoclonal Gammopathy of Undetermined Significance (MGUS)
- Amyloidosis

The test is safe, aiding in disease monitoring and diagnosis.

Who Should Get Tested

The Bence Jones protein test is essential for diagnosing systemic diseases, particularly multiple myeloma. This test detects abnormal light chain proteins in urine, which are not typically present in healthy individuals. Key points include:

- Who Needs Testing? Individuals suspected of having multiple myeloma or related conditions.
- Test Procedure: Involves collecting a urine sample, often using a clean-catch method.
- Detection Methods: Urine Immunofixation Electrophoresis, Free Light Chain Assay, and Urine Protein Electrophoresis.
- Indications: Presence of Bence Jones proteins suggests multiple myeloma, MGUS, amyloidosis, or lymphatic cancers.
- Safety: The test is safe, involving normal urination without discomfort.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for interpreting the Bence Jones protein test. This test detects abnormal proteins in urine, often linked to multiple myeloma. Key points include:

- Normal Results: No Bence Jones proteins detected.
- Abnormal Results: Presence of proteins suggests possible systemic diseases.
- Associated Conditions: Multiple myeloma, MGUS, amyloidosis, and lymphatic cancers.
- Further Investigation: Abnormal results require additional tests for accurate diagnosis.
- Safety: The test is safe, involving standard urine collection.

Understanding these results helps guide further medical evaluation and treatment.

Price of test:£34

The lowest price from the last 30 days: £34

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