Benzodiazepines
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The benzodiazepines are a class of drugs with sedative, hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. They are often used for short-term relief of severe, disabling anxiety or insomnia. Long-term use may lead to tolerance and dependency. They are believed to act on the GABA receptor GABAA, the activation of which dampens higher neuronal activity. They began to be widely prescribed for stress-related ailments in the 1960s and 1970s. Their chemical structure is based upon diazepine and phenyl groups. Common benzodiazepines include diazepam, oxazepam, chlorodiazepam, alprozolam, and temazepam.
The benzodiazepines are a class of drugs with sedative, hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. They are often used for short-term relief of severe, disabling anxiety or insomnia. Long-term use may lead to tolerance and dependency. They are believed to act on the GABA receptor GABAA, the activation of which dampens higher neuronal activity. They began to be widely prescribed for stress-related ailments in the 1960s and 1970s. Their chemical structure is based upon diazepine and phenyl groups. Common benzodiazepines include diazepam, oxazepam, chlorodiazepam, alprozolam, and temazepam.
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Purpose of the test
This test is designed to detect the presence of benzodiazepines in the blood. Benzodiazepines are medications that depress the central nervous system and are commonly used for sedation, sleep induction, seizure prevention, anxiety relief, and muscle relaxation. They can be prescribed for medical purposes but are also sometimes used illegally. Overdose or misuse of these drugs can lead to severe health complications.
Who Should Get Tested
Individuals who have been prescribed benzodiazepines might be tested to monitor therapeutic levels or to detect overdose. Additionally, if someone shows signs of overdose, such as confusion, slurred speech, loss of muscle control, or shallow breathing, they might be tested. The test can also be used in situations where benzodiazepine abuse is suspected, or in cases of potential drug-facilitated crimes, like date rape.
Blood Test Preparation Guidelines
Time of day
It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.
Fasting
It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.
Stay hydrated
Drinking water prior to testing can help with sample collection.
Other factors
Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.
Medications and supplements:
Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.
Biotin supplements:
High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.
Interpreting Test Results
The results of the blood test can be either positive or negative. A positive result indicates the presence of benzodiazepines in the blood, while a negative result means they are not present. The test can also measure the specific amount of the drug in the bloodstream. In cases of overdose or prolonged use, an antidote called flumazenil might be used to counteract the sedative effects of benzodiazepines, but it's not suitable for everyone.
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