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Beta 2 Microglobulin

Beta 2 Microglobulin

The Beta-2 microglobulin (B2M) test is a crucial diagnostic tool used to evaluate and monitor various medical conditions, particularly hematologic malignancies and renal disorders. B2M is a small protein integral to the immune system, found on the surface of all nucleated cells as part of the major histocompatibility complex (MHC) class I. Clinically, the B2M test is significant in assessing the prognosis of diseases like multiple myeloma and lymphoproliferative disorders, where elevated B2M levels often indicate increased cell turnover and poorer prognosis. It also aids in differentiating renal tubular disorders from glomerular diseases, assessing kidney function, and monitoring cancer treatment responses. The test involves collecting a blood sample, typically analyzed using nephelometry, a sensitive method for measuring B2M levels. Elevated B2M can indicate various conditions, including chronic inflammation and kidney dysfunction, making it a vital marker in clinical practice for informed patient care decisions.

Price of test:£149

The lowest price from the last 30 days: £149

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Beta-2 microglobulin (B2M) is a key protein in the immune system, integral to MHC class I on nucleated cells. It helps the immune system recognize foreign substances. The B2M test is crucial for:

- Prognosis in Hematologic Malignancies: High B2M levels indicate poor prognosis in multiple myeloma.
- Disease Monitoring: Tracks progression in lymphoproliferative disorders.
- Renal Function: Differentiates between renal disorders.
- Cancer Treatment: Monitors response to therapy.

Blood samples are analyzed using nephelometry. Elevated B2M levels suggest various conditions, including malignancies and kidney dysfunction.

Who Should Get Tested

The B2M test is crucial for assessing and monitoring certain diseases. Key applications include:

- Multiple Myeloma: B2M helps stage and predict disease progression.
- Lymphoproliferative Disorders: Differentiates and assesses severity.
- Renal Tubular Disorders: Distinguishes between glomerular and tubular diseases.
- Kidney Function: Assesses renal health, especially in transplant recipients.
- Cancer Treatment Monitoring: Tracks response to therapy.

Elevated B2M levels can indicate hematologic malignancies, kidney dysfunction, and more. Proper collection and handling ensure accurate results, aiding in effective patient care.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for Beta-2 microglobulin (B2M) is essential for evaluating various health conditions. Elevated B2M levels can indicate:

- Hematologic Malignancies: High levels suggest poor prognosis in multiple myeloma.
- Lymphoproliferative Disorders: Helps differentiate and assess severity.
- Renal Disorders: Distinguishes between glomerular and tubular diseases.
- Kidney Function: Assesses renal health, especially post-transplant.
- Cancer Treatment: Monitors therapy response.

Proper sample collection and handling are vital for accurate results. Understanding these aspects aids in effective disease management and prognosis.

Price of test:£149

The lowest price from the last 30 days: £149

AI-Powered Insights and Expert Validation

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