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Clostridium Difficile Toxin PCR

Clostridium Difficile Toxin PCR

Carbohydrate-deficient transferrin (CDT) is a specialized laboratory test designed to detect chronic and excessive alcohol consumption by measuring specific variants of the protein transferrin. Produced in the liver, transferrin typically contains multiple sialic acid residues. However, in individuals with high alcohol intake, these residues are reduced, resulting in carbohydrate-deficient transferrin. The test primarily measures disialotransferrin and asialotransferrin, which are indicative of chronic alcohol abuse. Utilizing high-performance liquid chromatography (HPLC), the CDT test analyzes blood samples to determine the percentage of carbohydrate-deficient transferrin, offering high specificity and sensitivity. Clinically, CDT aids in diagnosing and monitoring alcohol misuse, while in forensic settings, it helps assess excessive alcohol consumption in contexts like driver licensing and aviation. Despite its accuracy, CDT levels can be influenced by factors such as liver disease and genetic variations. The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) has standardized CDT measurement, ensuring consistent and reliable results across laboratories.

Price of test:£176

The lowest price from the last 30 days: £176

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Carbohydrate-deficient transferrin (CDT) is a crucial biomarker for detecting chronic alcohol consumption. It is highly specific and sensitive, making it valuable in clinical and forensic settings. CDT is a variant of transferrin with reduced sialic acid residues due to excessive alcohol intake. The test involves:

- Analyzing blood samples using high-performance liquid chromatography (HPLC).
- Measuring disialotransferrin as the primary analyte.

Applications include:

- Diagnosing and monitoring alcohol misuse.
- Assessing drinking habits in forensic cases.

Despite some limitations, CDT remains a reliable marker for alcohol-related disorders.

Who Should Get Tested

The Clostridioides difficile Toxin PCR test is crucial for diagnosing C. difficile infections, especially in patients with recent antibiotic use. Key points include:

- Specimen Collection: Fresh fecal samples are needed, collected in specific transport vials.
- Test Methodology: Uses real-time PCR to detect genes tcdB and tcdC, ensuring high specificity.
- Performance: Offers 91-96% sensitivity and 96-98% specificity.
- Clinical Utility: Rapid results aid in timely treatment, reducing hospital stays.
- Limitations: Not for test of cure; results should align with clinical findings.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for Carbohydrate-Deficient Transferrin (CDT) involves recognizing its role in detecting chronic alcohol consumption. Key points include:

- Specificity and Sensitivity: CDT is highly specific and sensitive, surpassing other markers like GGT and MCV.
- Clinical Use: Helps diagnose and monitor chronic alcohol misuse, aiding in treatment and relapse detection.
- Forensic Application: Assesses excessive alcohol consumption in legal contexts, such as driver licensing.
- Limitations: Not suitable for CDG syndrome or during pregnancy.
- Standardization: IFCC-approved HPLC ensures consistent results across labs.

Price of test:£176

The lowest price from the last 30 days: £176

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