The CA72-4 lab test measures the levels of cancer antigen 72-4, a tumor marker associated with various adenocarcinomas, including those of the stomach, pancreas, colon, ovaries, and breast. Identified in the 1980s, CA72-4 is part of the TAG-72 glycoprotein complex and is recognized by specific monoclonal antibodies. Its clinical utility lies in detecting elevated antigen levels in the serum, which may indicate the presence of cancer cells. While CA72-4 has a high specificity exceeding 95%, its sensitivity varies, being around 40-50% for colorectal and gastric cancers and about 50% for ovarian cancer. The test is particularly useful for monitoring cancer progression and recurrence. However, elevated CA72-4 levels can also occur in non-cancerous conditions, necessitating its use alongside other diagnostic tools. Combining CA72-4 with other markers like CEA and CA19-9 can improve diagnostic accuracy, making it a valuable adjunct in cancer diagnosis and monitoring.
The CA72-4 lab test measures the levels of cancer antigen 72-4, a tumor marker associated with various adenocarcinomas, including those of the stomach, pancreas, colon, ovaries, and breast. Identified in the 1980s, CA72-4 is part of the TAG-72 glycoprotein complex and is recognized by specific monoclonal antibodies. Its clinical utility lies in detecting elevated antigen levels in the serum, which may indicate the presence of cancer cells. While CA72-4 has a high specificity exceeding 95%, its sensitivity varies, being around 40-50% for colorectal and gastric cancers and about 50% for ovarian cancer. The test is particularly useful for monitoring cancer progression and recurrence. However, elevated CA72-4 levels can also occur in non-cancerous conditions, necessitating its use alongside other diagnostic tools. Combining CA72-4 with other markers like CEA and CA19-9 can improve diagnostic accuracy, making it a valuable adjunct in cancer diagnosis and monitoring.
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The CA72-4 lab test serves as a crucial tool in cancer diagnosis and monitoring, particularly for adenocarcinomas. Key points include:
- Tumor Marker: CA72-4 is part of the TAG-72 glycoprotein complex, primarily expressed in adenocarcinomas.
- Sensitivity and Specificity: Varies by cancer type; generally high specificity but moderate sensitivity.
- Clinical Utility: Useful in monitoring cancer progression and recurrence.
- Combination with Other Biomarkers: Enhances diagnostic accuracy when combined with markers like CEA and CA19-9.
- Quantification: Measured using ELISA kits, with positivity rates influenced by cut-off points.
CA72-4 testing is crucial for individuals at risk of adenocarcinomas, particularly in the pancreas, stomach, colon, ovaries, and breast. Key groups include:
- Patients with symptoms suggestive of these cancers.
- Individuals with a family history of adenocarcinomas.
- Those undergoing cancer treatment, for monitoring progression or recurrence.
- Patients with elevated levels of other tumor markers, like CA125 or CA19-9.
While CA72-4 offers valuable insights, it should be used alongside other diagnostic tools for a comprehensive evaluation.
Understanding test results for the CA72-4 lab test involves interpreting the levels of this tumor marker in the context of cancer diagnosis and monitoring. Key points to consider include:
- Sensitivity and Specificity: CA72-4 has moderate sensitivity but high specificity, making it useful for confirming cancer presence.
- Cancer Types: Primarily associated with adenocarcinomas like gastric, ovarian, and pancreatic cancers.
- Combination with Other Markers: Enhances diagnostic accuracy when used alongside markers like CA125 or CA19-9.
- Clinical Context: Elevated levels should be interpreted with other diagnostic tools for a comprehensive assessment.
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