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Coombs (Direct Antiglobulin Test)

Coombs (Direct Antiglobulin Test)

The Cod Fish IgG test is a specialized laboratory examination aimed at detecting immunoglobulin G (IgG) antibodies against cod fish in a patient's serum. It is part of a broader category of food-specific IgG tests used to identify immunologic sensitization to various food allergens. The primary purpose of this test is to assist clinicians in evaluating whether a patient's symptoms, such as gastrointestinal issues or skin rashes, might be linked to an immune response to cod fish. However, it is important to note that the presence of IgG antibodies does not confirm a food allergy, as food allergies are typically associated with IgE antibodies. The test is conducted using an enzyme immunoassay (EIA) and requires a serum sample. While the Cod Fish IgG test provides valuable insights into immunologic sensitization, it should be used alongside other diagnostic methods and clinical judgment to ensure accurate diagnosis and treatment.

Price of test:£83

The lowest price from the last 30 days: £83

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Cod Fish IgG test is a laboratory examination aimed at detecting IgG antibodies against cod fish in a patient's serum. It helps clinicians assess potential immune responses related to cod fish consumption. However, the presence of IgG antibodies alone does not confirm a food allergy, as allergies are typically linked to IgE antibodies. Key points include:

- Clinical Utility: Used in specific cases for dietary elimination and challenge.
- Procedure: Conducted using enzyme immunoassay.
- Specimen Handling: Requires careful storage, preferably refrigerated.
- Interpretation: Indicates sensitization, not necessarily symptoms.
- Applications: Useful for dietary management and monitoring sensitization.

Who Should Get Tested

The Coombs test is essential for diagnosing conditions where the immune system targets red blood cells (RBCs). It identifies antibodies or complement proteins on RBCs, crucial for diagnosing autoimmune hemolytic anemia (AIHA) and other disorders. The procedure involves:

- Blood sample collection
- Washing RBCs
- Incubation with Coombs reagent
- Observing agglutination

A positive result indicates antibodies or complement proteins on RBCs, linked to conditions like AIHA, hemolytic transfusion reactions, and erythroblastosis fetalis. Despite its value, the test can yield false positives and requires clinical context for interpretation.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Cod Fish IgG test involves recognizing its role in identifying immunologic sensitization to cod fish. Key points include:

- Clinical Context: IgG antibodies suggest sensitization, not necessarily an allergy.
- Procedure: Conducted via enzyme immunoassay, requiring a serum sample.
- Specimen Handling: Refrigerate for up to 7 days; freeze if longer storage is needed.
- Interpretation: Results should be evaluated alongside medical history and other tests.
- Turnaround: Typically 3 business days.
- Limitations: Not FDA-approved for diagnostic use; should complement other methods.

Price of test:£83

The lowest price from the last 30 days: £83

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