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C1 Esterase Inhibitor

C1 Esterase Inhibitor

The Complement C1q test is a laboratory assay designed to measure the levels of the C1q protein, a vital component of the complement system, which enhances the ability of antibodies and phagocytic cells to clear pathogens. C1q is the first protein in the classical pathway of the complement system, initiating a cascade of reactions crucial for pathogen neutralization. This test is primarily used to diagnose and manage immune system dysfunctions, such as autoimmune diseases like systemic lupus erythematosus (SLE), and congenital deficiencies that increase susceptibility to infections. The test employs radial immunodiffusion (RID) to quantify C1q levels in serum samples, which are collected in red-top or gel-barrier tubes. Results are reported in mg/dL, with specific reference intervals based on age and gender. Low C1q levels can indicate congenital or acquired deficiencies, aiding in the diagnosis of conditions like SLE, immune complex diseases, and complement deficiencies. The test typically has a turnaround time of 7 to 11 days.

Price of test:£126

The lowest price from the last 30 days: £126

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Complement C1q test is crucial for diagnosing immune dysfunctions. It measures C1q protein levels, essential for the complement system's classical pathway. Key points include:

- Purpose: Diagnoses autoimmune diseases like SLE and congenital deficiencies.
- Methodology: Uses radial immunodiffusion to quantify C1q.
- Specimen Requirements: Serum in a red-top tube; avoid plasma.
- Causes for Rejection: Chylous, lipemic, or contaminated samples.
- Interpretation: Low C1q suggests deficiencies or consumption.
- Clinical Applications: Useful for SLE, congenital, and acquired deficiencies.
- Turnaround Time: Typically 7-11 days.

Who Should Get Tested

The Complement C1q test is crucial for diagnosing immune system dysfunctions. It measures C1q protein levels, essential for the complement system's role in pathogen clearance. Key applications include:

- Systemic Lupus Erythematosus (SLE): Low C1q levels indicate complement consumption.
- Congenital Deficiencies: Inherited issues lead to infection susceptibility.
- Acquired Deficiencies: Autoantibodies can reduce C1q levels.
- Immune Complex Diseases: Conditions like glomerulonephritis show low C1q.

A serum sample is required, with results aiding in tailored treatment strategies.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Complement C1q test is crucial for diagnosing immune-related conditions. Here's a brief guide:

- Normal Ranges: Vary by age and gender, with adults typically having 10.2-20.3 mg/dL (male) and 10.3-20.5 mg/dL (female).
- Low Levels: May indicate congenital or acquired deficiencies, or complement consumption due to infections or autoimmune diseases.
- Clinical Implications: Useful in diagnosing systemic lupus erythematosus, congenital deficiencies, and immune complex diseases.
- Interpretation: Requires careful analysis of C1q levels alongside other complement components for accurate diagnosis.

Price of test:£126

The lowest price from the last 30 days: £126

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