Cod Fish IgE

The Coombs test, or direct antiglobulin test (DAT), is a vital laboratory procedure used to detect antibodies or complement proteins attached to red blood cells (RBCs), which can lead to their destruction and anemia. This test is crucial for diagnosing autoimmune hemolytic anemia (AIHA), where the immune system mistakenly attacks RBCs. It also helps identify hemolytic transfusion reactions, erythroblastosis fetalis in newborns, and drug-induced hemolysis. The procedure involves collecting a blood sample, washing the RBCs, and incubating them with Coombs reagent. Agglutination, or clumping of RBCs, indicates a positive result, suggesting antibodies or complement proteins are present. Conditions associated with positive results include AIHA, transfusion reactions, and certain infections. While the Coombs test is reliable, it can produce false positives and must be interpreted alongside clinical findings. Despite its limitations, the Coombs test remains an essential tool in diagnosing and managing hemolytic disorders.

Price of test:£34

The lowest price from the last 30 days: £34

Awaiting result:

One day

Collect material:

Blood

Prepare:

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Purpose of the test

The Coombs test is a vital diagnostic tool in immunohematology, used to detect antibodies or complement proteins on red blood cells (RBCs). It helps diagnose conditions like autoimmune hemolytic anemia (AIHA) and hemolytic transfusion reactions. The procedure involves:

- Blood Sample Collection: Obtaining a sample from the patient.
- Washing of RBCs: Removing unbound antibodies.
- Incubation with Coombs Reagent: Adding antihuman globulin.
- Agglutination: Observing clumping for positive results.

Positive results indicate potential RBC destruction. Despite its utility, the test can yield false positives and requires clinical context for interpretation.

Who Should Get Tested

The Cod Fish IgE test is essential for individuals suspected of having a cod fish allergy. It identifies specific IgE antibodies, aiding in diagnosing allergic reactions. Key points include:

- Purpose: Diagnoses cod fish allergy, confirms sensitization before immunotherapy.
- Method: Uses Fluorescence Enzyme Immunoassay (FEIA) with ImmunoCAPs.
- Specimen: Requires serum, stored at 2-8°C or frozen at -20°C.
- Results: Classified from Class 0 (negative) to Class 6 (very high positive).
- Limitations: Not for post-immunotherapy sensitivity; false positives possible with high IgE levels.

This test is crucial for effective allergy management.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for accurate diagnosis and effective patient management. The Coombs test, or direct antiglobulin test (DAT), is essential for identifying antibodies or complement proteins on red blood cells (RBCs). Here's a brief overview:

- Negative Result: No clumping indicates no antibodies or complement proteins on RBCs.
- Positive Result: Agglutination suggests antibodies or complement proteins are present, potentially leading to RBC destruction.

Conditions linked to positive results include autoimmune hemolytic anemia, hemolytic transfusion reactions, and erythroblastosis fetalis. Understanding these results helps in diagnosing and managing hemolytic disorders.

Price of test:£34

The lowest price from the last 30 days: £34

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