Cystatin-C

The Cyclosporin Level (Monoclonal) test is a vital laboratory assay used to measure cyclosporine concentration in whole blood, primarily for transplant patients. Cyclosporine is a crucial immunosuppressant that helps prevent organ rejection. This test ensures that cyclosporine levels remain within a therapeutic range, optimizing immunosuppression while minimizing toxicity risks. Blood samples are collected in EDTA tubes before the next dose to measure trough concentrations accurately. The test employs a monoclonal immunoassay, often using liquid chromatography-tandem mass spectrometry (LC-MS/MS), providing high specificity and sensitivity by minimizing cross-reactivity with metabolites. Therapeutic ranges vary based on transplant type and clinical protocols, generally between 100 to 400 ng/mL. Monitoring cyclosporine levels aids in optimizing immunosuppression, minimizing toxicity, evaluating patient compliance, and adjusting doses. Despite challenges like assay variability and metabolite cross-reactivity, this test remains essential for effective management of transplant patients, ensuring accurate and reliable cyclosporine monitoring.

Price of test:£104

The lowest price from the last 30 days: £104

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Cyclosporin Level (Monoclonal) test is vital for managing transplant patients by measuring cyclosporine concentration in whole blood. It ensures therapeutic levels are maintained to prevent organ rejection and minimize toxicity. Key aspects include:

- Purpose: Monitor cyclosporine levels for optimal immunosuppression.
- Sample Handling: Collect whole blood in EDTA tubes before the next dose.
- Analytical Method: Use monoclonal immunoassay and LC-MS/MS for accuracy.
- Therapeutic Ranges: Adjust based on transplant type and patient needs.
- Clinical Significance: Optimize therapy, minimize toxicity, and assess compliance.

Who Should Get Tested

The cystatin-C test is crucial for evaluating kidney function, especially when traditional tests like serum creatinine are unreliable. This blood test measures cystatin-C, a protein filtered by the kidneys, to assess glomerular filtration rate (GFR). It's particularly useful in:

- Unclear previous test results
- Individuals with abnormal muscle mass
- Age and gender variations
- Cases of malnutrition and obesity

High cystatin-C levels indicate low eGFR, suggesting potential chronic kidney disease. Its accuracy and early detection capabilities make it indispensable for healthcare providers in diagnosing and managing kidney issues effectively.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Cyclosporin Level (Monoclonal) test is crucial for effective patient management. This test measures cyclosporine concentration in whole blood, vital for transplant patients to prevent organ rejection. Key points include:

- Purpose: Ensures therapeutic cyclosporine levels for optimal immunosuppression.
- Sample Collection: Whole blood in EDTA tube, drawn before the next dose.
- Method: Monoclonal immunoassay with LC-MS/MS for accuracy.
- Therapeutic Ranges: Vary by transplant type; typically 100-400 ng/mL.
- Clinical Significance: Optimizes immunosuppression, minimizes toxicity, evaluates compliance, and guides dosage adjustments.

Price of test:£104

The lowest price from the last 30 days: £104

AI-Powered Insights and Expert Validation

Advanced AI Interpretation

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Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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