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D4 Androstenedione

D4 Androstenedione

The androstenedione test is a vital diagnostic tool in the assessment of adrenal and gonadal function, focusing on the measurement of serum androstenedione levels, a key sex-steroid precursor. Predominantly produced by the adrenal glands and, to a lesser extent, the gonads, androstenedione plays a crucial role in androgen production regulation. Clinically, this test is essential for evaluating adrenal gland function and identifying abnormalities in hormone production, such as hyperandrogenism. It is particularly significant in diagnosing congenital adrenal hyperplasia (CAH), a group of inherited disorders leading to excessive androgen production, and in monitoring CAH treatment to ensure effective management of androgen levels. Additionally, the test aids in diagnosing premature adrenarche, characterized by early puberty signs due to elevated adrenal androgens. Utilizing liquid chromatography/tandem mass spectrometry (LC/MS-MS), the test provides precise androstenedione quantification, offering valuable insights for clinicians in managing androgen-related disorders and ensuring optimal hormonal balance.

Price of test:£99

The lowest price from the last 30 days: £99

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Androstenedione testing serves as a vital diagnostic tool in assessing adrenal and gonadal function. It helps in:

- Diagnosing congenital adrenal hyperplasia (CAH)
- Monitoring CAH treatment effectiveness
- Identifying premature adrenarche

The test measures serum androstenedione levels, offering insights into androgen production. Elevated levels can indicate conditions like hyperandrogenism or adrenal tumors. Specimens are collected in serum tubes, stored at 2-8°C, and analyzed using LC/MS-MS. This precise method ensures accurate results, aiding clinicians in managing androgen-related disorders effectively.

Who Should Get Tested

Androstenedione testing is vital for assessing adrenal and gonadal function. Key groups needing this test include:

- Individuals with suspected hyperandrogenism: Elevated androgens may indicate adrenal or gonadal issues.
- Patients with Congenital Adrenal Hyperplasia (CAH): Regular monitoring helps manage treatment.
- Children with premature adrenarche: Differentiates from other puberty-related conditions.
- Women with polycystic ovarian syndrome (PCOS): Helps evaluate androgen levels.

This test aids in diagnosing and managing conditions linked to abnormal androgen production, ensuring effective treatment and monitoring.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for androstenedione involves interpreting serum levels to assess adrenal and gonadal function. Key points include:

- Clinical Use: Evaluates adrenal function, diagnoses hyperandrogenism, and differentiates conditions like CAH.
- Diagnosis: Essential for identifying CAH and premature adrenarche.
- Monitoring: Regular testing helps manage CAH treatment.
- Reference Ranges: Vary by age and sex; elevated levels may indicate disorders.
- Specimen Requirements: Serum collected in specific tubes, stored properly.
- Methodology: Uses LC/MS-MS for precise measurement.
- Clinical Significance: Elevated levels can signal serious conditions.

Price of test:£99

The lowest price from the last 30 days: £99

AI-Powered Insights and Expert Validation

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