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Dengue IgG/IgM antibodies

Dengue IgG/IgM antibodies

The laboratory test for detecting Dengue IgG and IgM antibodies is essential for diagnosing dengue virus infections, particularly in regions where dengue fever is prevalent. This test helps differentiate between primary and secondary infections, which have varying clinical outcomes. The test identifies IgG antibodies, indicating past exposure, and IgM antibodies, suggesting a recent or current infection. It is often used alongside other diagnostic methods, such as nucleic acid amplification tests or NS1 antigen tests, to confirm dengue diagnosis. IgG antibodies are detectable in most individuals by three weeks post-exposure and can persist for extended periods, while IgM antibodies appear within 3 to 7 days of infection and may remain detectable for up to 6 months. The test involves collecting serum specimens and using Enzyme-Linked Immunosorbent Assay (ELISA) to detect antibodies. Cross-reactivity with other flaviviruses can occur, necessitating careful interpretation of results. This test is crucial for diagnosing dengue, guiding treatment, and informing public health strategies.

Price of test:£132

The lowest price from the last 30 days: £132

Awaiting result:

6 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The laboratory test for detecting Dengue IgG and IgM antibodies is essential for diagnosing dengue virus infections. It helps differentiate between primary and secondary infections, which have distinct clinical outcomes.

- Purpose: Detect IgG (past exposure) and IgM (recent infection) antibodies.
- IgG Antibodies: Indicate past exposure; persist long-term.
- IgM Antibodies: Indicate recent infection; appear early.
- Diagnostic Algorithm: Compare acute and convalescent sera.
- Methodology: ELISA detects antibodies; cross-reactivity possible.
- Clinical Utility: Guides treatment, distinguishes infection types, aids epidemiology.

Who Should Get Tested

In regions where dengue fever is endemic, testing for Dengue IgG and IgM antibodies is essential. This test helps identify past or current infections and distinguishes between primary and secondary infections, which can have different clinical outcomes.

- IgG Antibodies: Indicate past exposure; persist long-term.
- IgM Antibodies: Indicate recent infection; appear early.

Testing involves collecting acute and convalescent sera to compare antibody levels. This helps determine infection type. Specimens must be handled carefully to ensure accuracy. ELISA is used for detection, but cross-reactivity with other flaviviruses can occur.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for dengue IgG and IgM antibodies is essential for accurate diagnosis and management. Here's a brief overview:

- IgG Antibodies: Indicate past exposure; persist long-term.
- IgM Antibodies: Suggest recent infection; appear early.
- Primary vs. Secondary Infections:
- Primary: Higher IgM than IgG.
- Secondary: Higher IgG than IgM.
- Specimen Handling: Use serum; avoid contamination.
- Methodology: ELISA detects antibodies; consider cross-reactivity.
- Clinical Utility: Guides treatment, distinguishes infection types, aids epidemiology.

Price of test:£132

The lowest price from the last 30 days: £132

AI-Powered Insights and Expert Validation

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