Filariasis

Filarial infections, caused by parasitic filarial nematodes, pose a significant health challenge globally. Diagnosing these infections primarily involves detecting microfilariae, the larval form of the parasite, in the blood. The standard diagnostic method is microscopic examination of blood smears, prepared from samples collected via fingerstick or venipuncture. These smears are stained with Giemsa or similar stains to highlight microfilariae. Timing of blood collection is crucial, as different filarial species release microfilariae at specific times; for instance, Wuchereria bancrofti is best detected between 10 PM and 2 AM. When microfilarial loads are low, concentration techniques like the Knott’s method enhance detection. Additionally, serologic tests, such as Enzyme Immunoassays, detect antibodies against filarial parasites, aiding diagnosis when microfilariae are absent in blood. Accurate diagnosis relies on proper specimen collection, processing, and understanding of clinical presentations, ensuring timely and effective treatment of filarial infections.

Price of test:£79

The lowest price from the last 30 days: £79

Awaiting result:

12 hours

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Filarial infections are diagnosed primarily through microscopic examination and serologic tests. Key steps include:

- Microscopic Examination:
- Collect blood samples at specific times for different filarial species.
- Prepare thick or thin blood smears.
- Stain with Giemsa or similar stains.
- Examine for microfilariae presence.

- Concentration Techniques:
- Use methods like Knott’s concentration for low microfilarial loads.
- Centrifuge to concentrate microfilariae.

- Serologic Testing:
- Collect blood in serum separator tubes.
- Perform EIA to detect antifilarial antibodies.
- Use acute and convalescent samples for confirmation.

These methods ensure accurate diagnosis and effective treatment initiation.

Who Should Get Tested

Filarial infections require precise diagnostic methods to ensure accurate detection and treatment. Key diagnostic steps include:

- Microscopic Examination: Collect blood samples at specific times for different filarial species. Prepare and stain blood films to identify microfilariae under a microscope.

- Concentration Techniques: Use methods like Knott’s concentration to enhance detection when microfilarial load is low.

- Serologic Testing: Perform Enzyme Immunoassay (EIA) to detect antifilarial antibodies, especially useful for amicrofilaremic patients.

Understanding clinical presentations and diagnostic challenges is crucial for effective diagnosis and treatment.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for filarial infections is crucial for accurate diagnosis and treatment. Here's a concise guide:

- Microscopic Examination: Blood smears are examined for microfilariae. Timing is key, as different species release microfilariae at specific times.
- Concentration Techniques: Used when microfilarial load is low, enhancing detection.
- Serologic Testing: Detects antibodies in blood, useful for low microfilarial loads or amicrofilaremic patients.
- Clinical Presentation: Recognize symptoms like lymphatic dysfunction and inflammation.
- Diagnostic Challenges: Proper specimen collection and processing are vital to avoid misidentification.

Price of test:£79

The lowest price from the last 30 days: £79

AI-Powered Insights and Expert Validation

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