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Gastric Parietal Cell Abs

Gastric Parietal Cell Abs

The gastric parietal cell antibody (GPCA) test is a blood test used to detect antibodies against the stomach's parietal cells, often linked to autoimmune conditions affecting the gastrointestinal system. Primarily, it helps diagnose pernicious anemia, a condition where the lack of intrinsic factor, produced by parietal cells, leads to vitamin B12 deficiency and megaloblastic anemia. The test is performed using an enzyme-linked immunosorbent assay (ELISA), involving steps like blood collection, serum separation, and incubation with specific antigens. Results are interpreted based on color intensity, indicating the presence of antibodies. While a positive result suggests pernicious anemia or other autoimmune diseases, the test's sensitivity means it should be considered alongside clinical symptoms and other tests. Despite its diagnostic utility, the GPCA test's specificity is limited, as antibodies can appear in healthy individuals or those with other autoimmune conditions. Proper sample handling and storage are crucial for accurate results, with a typical turnaround time of 2-4 days.

Price of test:£79

The lowest price from the last 30 days: £79

Awaiting result:

7 days

Collect material:

Blood

Prepare:

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Purpose of the test

The gastric parietal cell antibody (GPCA) test is a blood test used to detect antibodies against stomach parietal cells, often linked to autoimmune conditions affecting the gastrointestinal system. Its primary purpose is to evaluate patients suspected of having pernicious anemia or vitamin B12 deficiencies. The test is performed using an enzyme-linked immunosorbent assay (ELISA) and involves several steps:

- Specimen collection and serum separation
- Assay preparation and incubation
- Washing and enzyme conjugation
- Color development and spectrophotometric measurement

Results are interpreted based on color intensity, indicating the presence of antibodies.

Who Should Get Tested

The gastric parietal cell antibody (GPCA) test is crucial for diagnosing autoimmune conditions affecting the gastrointestinal system, particularly pernicious anemia. This blood test detects IgG antibodies against stomach parietal cells, essential for vitamin B12 absorption. Key points include:

- Purpose: Evaluates suspected pernicious anemia or vitamin B12 deficiencies.
- Procedure: Involves ELISA, serum separation, antigen binding, and spectrophotometric measurement.
- Interpretation: Results range from negative to positive, indicating antibody presence.
- Clinical Significance: Suggests pernicious anemia or other autoimmune diseases.
- Limitations: High sensitivity but not specific; requires clinical context for interpretation.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for accurate diagnosis and management. The GPCA test detects antibodies against stomach parietal cells, aiding in diagnosing pernicious anemia and related conditions. Here's a brief guide:

- Negative: ≤20.0 Units, no detectable antibodies.
- Equivocal: 20.1-24.9 Units, inconclusive; consider retesting.
- Positive: ≥25.0 Units, suggests autoimmune conditions.

A positive result indicates potential pernicious anemia, but context is key due to the test's sensitivity and lack of specificity. Always consider clinical symptoms and other tests for a comprehensive evaluation.

Price of test:£79

The lowest price from the last 30 days: £79

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