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Hepatitis Delta Antibody

Hepatitis Delta Antibody

The Hepatitis E IgG Antibody Test is a vital diagnostic tool used to detect IgG antibodies against the hepatitis E virus (HEV) in human serum, indicating past exposure. Utilizing an indirect sandwich enzyme-linked immunosorbent assay (ELISA), the test involves several key steps: purified HEV antigens are fixed to microplate wells, patient serum is incubated to allow antibody binding, and unbound antibodies are washed away. A conjugate is then added, and a color reaction reveals the presence of HEV IgG antibodies. Clinically, the test helps differentiate between past and present HEV infections, guiding patient care and management. Positive results confirm past exposure, while negative results suggest no prior exposure, though recent infections may require further testing. The test is performed in CLIA-certified labs, offering high specificity and sensitivity. It plays a crucial role in global health, particularly in regions with poor sanitation, where HEV is a leading cause of acute hepatitis.

Price of test:£208

The lowest price from the last 30 days: £208

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Hepatitis E IgG antibody test is a vital diagnostic tool for detecting past exposure to the hepatitis E virus (HEV). Utilizing an indirect sandwich ELISA method, the test identifies IgG antibodies in human serum. Key steps include:

- Antigen Preparation: Recombinant HEV-ORF2 antigens are fixed to microplate wells.
- Serum Incubation: Patient serum binds to these antigens.
- Washing Step: Unbound antibodies are removed.
- Conjugate Addition: Anti-human IgG antibodies are added.
- Detection: A color reaction indicates antibody presence.

Positive results suggest past exposure, aiding in immune status assessment and reinfection risk evaluation.

Who Should Get Tested

The Hepatitis Delta Antibody test is essential for detecting HDV in patients with HBV. It is crucial for:

- Diagnosing HDV in acute or chronic HBV cases.
- Identifying HDV superinfection, which worsens HBV prognosis.

The test uses Enzyme Immunoassay to detect HDV antibodies in serum. Proper specimen handling is vital, with serum separated and frozen promptly. Results interpretation includes:

- Negative: No HDV infection.
- Positive: Coinfection, superinfection, or resolved infection.

Limitations include false positives and challenges in immunocompromised patients. Reflex testing for HDV RNA may follow positive results to confirm infection status.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for managing patient care effectively. Here's a brief guide:

- Positive Results: Indicates past exposure to HEV, helping assess immune status and reinfection risk.

- Negative Results: Suggests no prior exposure, but recent infection can't be ruled out, especially in immunocompromised patients. Consider retesting.

- Borderline Results: May indicate acute or recent infection. Retesting in 4-6 weeks is advised for clarity.

Understanding these outcomes aids in differentiating between past and present infections, ensuring appropriate medical interventions.

Price of test:£208

The lowest price from the last 30 days: £208

AI-Powered Insights and Expert Validation

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Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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