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Hepatitis E IgG

Hepatitis E IgG

The Hepatitis E IgM test is a vital diagnostic tool for detecting acute hepatitis E infections by identifying IgM antibodies against the hepatitis E virus (HEV) in a patient's serum. These antibodies typically appear within 1-4 weeks after symptom onset, making them essential for diagnosing recent infections. Hepatitis E is a significant public health issue, especially in regions with poor sanitation, and is primarily transmitted via the fecal-oral route. In developed countries, it often affects travelers to endemic areas or those consuming undercooked meat from infected animals. The test employs an enzyme-linked immunosorbent assay (ELISA) method, using recombinant HEV antigens to detect virus-specific IgM antibodies. Proper specimen collection, handling, and shipping are crucial for accurate results. Positive results indicate recent infection, while negative results suggest its absence. The test's specificity and sensitivity are critical for distinguishing hepatitis E from other viral hepatitis forms, aiding in effective clinical management and treatment.

Price of test:£63

The lowest price from the last 30 days: £63

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Hepatitis E IgM test is vital for diagnosing acute hepatitis E infections by detecting IgM antibodies in serum. Key points include:

- Clinical Utility: Essential in regions with poor sanitation; differentiates hepatitis E from other viral hepatitis forms.
- Test Procedure:
- Collect serum using SST or similar tubes.
- Handle and store specimens properly to ensure accuracy.
- Perform ELISA to detect IgM antibodies.
- Result Interpretation: Positive indicates recent infection; negative suggests absence.
- Special Considerations: Repeat testing may be needed, especially in immunocompromised patients.

Who Should Get Tested

The Hepatitis E IgG antibody test is essential for identifying past exposure to the hepatitis E virus (HEV). It uses an indirect sandwich ELISA method to detect IgG antibodies in human serum, providing insights into an individual's immune status and risk of reinfection. Key steps include:

- Antigen Preparation: Recombinant HEV antigens are fixed to microplate wells.
- Serum Incubation: Patient serum binds to these antigens.
- Detection: A color reaction indicates antibody presence.

Positive results confirm past exposure, while negative results suggest no prior infection. This test is vital for managing patient care and preventing complications.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Hepatitis E IgM test is crucial for accurate diagnosis and management of acute hepatitis E infections. This test detects IgM antibodies, which appear 1-4 weeks after symptom onset, indicating recent infection. Key points include:

- Positive Result: Indicates acute or recent hepatitis E infection.
- Negative Result: Suggests absence of recent infection, but repeat testing may be needed, especially in immunocompromised patients.
- Indeterminate Result: May occur due to rising or declining antibody levels, HEV genotype 2, or cross-reactivity.

Repeat testing in 4-6 weeks can confirm infection status.

Price of test:£63

The lowest price from the last 30 days: £63

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