HFE Gene Test

The hippuric acid urine test is a diagnostic procedure designed to assess exposure to aromatic solvents like toluene, benzyl alcohol, and xylene. By measuring hippuric acid levels and its metabolites in urine, the test provides crucial insights into an individual's exposure to these chemicals, commonly found in industrial environments such as manufacturing and construction. Prolonged exposure can lead to serious health issues, including neurological and kidney damage. The test requires a random urine sample, ideally collected at the end of a work shift, and employs advanced techniques like Gas Chromatography and High-Performance Liquid Chromatography for analysis. Results are normalized using creatinine levels to ensure accuracy. Reference intervals help interpret the results, distinguishing between normal, exposed, and potentially toxic levels. With a typical turnaround time of seven days, this test is vital for occupational health monitoring, environmental assessments, and clinical diagnosis, ensuring safety and health in environments where exposure to these solvents is a concern.

Price of test:£425

The lowest price from the last 30 days: £425

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The hippuric acid urine test is designed to evaluate exposure to aromatic solvents like toluene, benzyl alcohol, and xylene. It measures hippuric acid levels in urine, offering insights into solvent exposure. Key aspects include:

- Purpose: Assess biological exposure to industrial solvents.
- Specimen Requirements: Random urine sample, 0.5 mL minimum, preferably 10 mL.
- Methodology: Utilizes GC/FID, spectrophotometry, and LC-MS/MS.
- Test Components: Measures creatinine, hippuric acid, and methylhippuric acid.
- Reference Intervals: Less than 1.6 g/L for unexposed; BEI is 1.5 g/g creatinine.
- Applications: Occupational health, environmental monitoring, clinical diagnosis.

Who Should Get Tested

The HFE gene test is essential for diagnosing hereditary hemochromatosis (HH), a condition marked by excessive iron absorption. Testing is crucial for:

- Individuals with Symptoms: Those showing signs of iron overload, such as liver damage or diabetes.
- Family History: People with relatives diagnosed with HH should consider testing.
- Clinical Indicators: Elevated serum ferritin or transferrin-iron saturation levels warrant testing.

The test identifies C282Y and H63D mutations, aiding in diagnosis and management. However, results must be interpreted alongside clinical data for accuracy.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for interpreting the hippuric acid urine test. This test evaluates exposure to aromatic solvents like toluene, benzyl alcohol, and xylene by measuring hippuric acid levels in urine. Key points include:

- Normal Results: Indicate no significant exposure, with concentrations below 1.6 g/L.
- Exposed Results: Suggest exposure, with levels around 1.5 g/g creatinine.
- Toxic Results: Indicate high exposure, potentially exceeding safe thresholds.

These results help assess occupational and environmental exposure, guiding necessary interventions.

Price of test:£425

The lowest price from the last 30 days: £425

AI-Powered Insights and Expert Validation

Advanced AI Interpretation

Diagu's AI system represents a breakthrough in medical test analysis, employing state-of-the-art algorithms meticulously trained on a vast spectrum of authoritative medical literature and data. This system intricately analyses laboratory test results, extracting nuanced insights that might elude conventional methods. Our AI delves into complex interrelations between various health markers, offering a comprehensive understanding that supports accurate diagnosis and effective treatment planning. The foundation of our AI's analytical prowess lies in its extensive training, encompassing data from globally recognised medical journals, trusted healthcare databases, and breakthrough scientific studies. This ensures that every analysis is grounded in the latest and most comprehensive medical knowledge.

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While our AI provides deep analytical insights, the human touch remains indispensable. Every AI-generated interpretation is meticulously reviewed by experienced medical professionals, ensuring a harmonious blend of advanced technology and expert clinical judgment. This dual-layer approach guarantees that the insights provided are not only technologically sophisticated but also clinically relevant. Our medical experts ensure that the AI's interpretations align with current medical standards and practices, adding a layer of validation that only seasoned healthcare professionals can provide. This process reinforces the reliability of the test results, offering peace of mind to both patients and healthcare providers.

Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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