HLA DQ2/DQ8

The HLA DQ2/DQ8 test is crucial for identifying individuals at risk for celiac disease, an autoimmune disorder triggered by gluten. This genetic test detects specific alleles linked to the disease. Key points include:

- Genetic Markers: HLA-DQ2 and HLA-DQ8 alleles are strongly associated with celiac disease.
- Testing Process: Involves DNA extraction, PCR amplification, probe hybridization, and result interpretation.
- Results:
- Absence of DQ2/DQ8: Low risk.
- Presence of DQ2/DQ8: Increased risk.
- Clinical Implications: Positive results indicate higher risk but not a definitive diagnosis.

Understanding test results from the HLA DQ2/DQ8 lab test is crucial for assessing genetic risk for celiac disease. Here's a brief guide:

- Negative Result: Absence of DQ2/DQ8 haplotypes suggests a low likelihood of developing celiac disease.
- Positive Result: Presence of DQ2 and/or DQ8 indicates a genetic predisposition, increasing risk significantly.
- Half DQ2: Detection of only one allele (HLA-DQA105 or HLA-DQB102) suggests a lower, yet elevated risk.

While these results highlight genetic risk, they don't confirm celiac disease, necessitating further clinical evaluation.