IGF-BP3

The Insulin-Like Growth Factor-Binding Protein 3 (IGFBP-3) serum test is an essential diagnostic tool for assessing growth hormone (GH) production and its impact on the body. IGFBP-3, a 264-amino acid peptide primarily produced by the liver, binds to insulin-like growth factors, particularly IGF-1, extending their half-life and stabilizing their effects on tissues. Clinically, the IGFBP-3 test is crucial for diagnosing growth disorders, such as short stature or gigantism, and adult GH deficiency, which can lead to decreased muscle mass and bone density. It also aids in monitoring recombinant human GH therapy and provides additional information in conditions like acromegaly. The test requires a serum sample, with results interpreted based on age-specific reference ranges. Factors such as nutrition and liver function can influence IGFBP-3 levels, and variability among assays necessitates careful interpretation. Overall, the IGFBP-3 test is a valuable tool in managing growth-related conditions.

Price of test:£167

The lowest price from the last 30 days: £167

Awaiting result:

7 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The IGFBP-3 serum test is essential for diagnosing and monitoring growth hormone-related conditions. Key objectives include:

- Diagnosing Growth Disorders: Assess IGFBP-3 levels to identify growth issues like short stature or gigantism.
- Adult GH Deficiency: Detect low IGFBP-3 levels indicating GH deficiency, affecting muscle mass and energy.
- Monitoring GH Therapy: Evaluate IGFBP-3 to gauge recombinant GH treatment effectiveness.
- Acromegaly and Gigantism: Support diagnosis with elevated IGFBP-3 levels.

Proper preparation and understanding of results are crucial for accurate diagnosis and treatment adjustments.

Who Should Get Tested

The IGFBP-3 serum test is crucial for diagnosing and monitoring growth hormone-related conditions. Key individuals who should be tested include:

- Children with Growth Disorders: Those exhibiting short stature or excessive growth.
- Adults Suspected of GH Deficiency: Symptoms like decreased muscle mass and energy levels.
- Patients on GH Therapy: To assess treatment effectiveness.
- Individuals with Acromegaly or Gigantism: For additional diagnostic support.

Proper preparation, such as avoiding biotin, ensures accurate results. Interpretation considers age and health factors, aiding in effective diagnosis and treatment monitoring.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the IGFBP-3 serum test is crucial for diagnosing and managing growth-related conditions. Here's a brief guide:

- Age-Dependent Levels: IGFBP-3 levels vary with age, peaking during puberty and slightly decreasing in adulthood.
- Clinical Context: Results should be interpreted considering the patient's age, nutritional status, and liver function.
- Discrepancies: Differences between IGFBP-3 and IGF-1 levels may indicate liver or kidney issues.
- Assay Variability: Different testing platforms may yield varying results; consistency in testing methods is recommended.

Price of test:£167

The lowest price from the last 30 days: £167

AI-Powered Insights and Expert Validation

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