Karyotype

The Kell antigen status test is an essential diagnostic procedure used to identify the presence of the Kell antigen on red blood cells, which is crucial for assessing the risk of hemolytic disease of the fetus and newborn (HDFN). This condition arises when maternal antibodies target fetal red blood cells expressing the Kell antigen, potentially leading to severe anemia and other complications. The test involves collecting a blood sample, typically in a lavender-top (EDTA) tube, and analyzing it using hemagglutination techniques to determine Kell antigen presence. Results indicate whether an individual is Kell positive, Kell negative, or heterozygous for the antigen. Understanding Kell status is vital in pregnancy management, blood transfusions, and genetic counseling, helping prevent adverse reactions and guide clinical decisions. Despite limitations like false-negative results and specimen quality issues, the test remains a critical tool in transfusion medicine and obstetrics, ensuring better management of red blood cell antigen-related disorders.

Price of test:£889

The lowest price from the last 30 days: £889

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Kell antigen status test is essential for assessing the risk of alloimmune hemolytic disease in newborns. This condition arises when maternal antibodies attack fetal red blood cells expressing the Kell antigen. The test involves:

- Specimen Collection: Collect 0.5 mL of blood in a lavender-top (EDTA) tube.
- Transportation: Quickly transport to the lab; refrigerate if needed.
- Testing Methodology: Use hemagglutination to detect the Kell antigen.
- Interpretation: Determine if Kell positive, negative, or heterozygous.

Understanding Kell status is crucial in pregnancy, blood transfusions, and genetic counseling.

Who Should Get Tested

A karyotype test is essential for identifying genetic disorders and abnormalities. It evaluates chromosomes to diagnose conditions affecting health and fertility. Key groups who may need this test include:

- Individuals with Genetic Disorders: Detects chromosomal abnormalities like Down syndrome.
- Couples Facing Fertility Issues: Identifies chromosomal causes affecting conception.
- Pregnant Women: Especially those over 35 or with a family history of genetic disorders.
- Cancer Patients: Bone marrow tests can reveal chromosomal changes linked to certain cancers.

The test involves collecting cell samples, which are analyzed to reveal chromosomal information.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Kell antigen status test is vital for managing potential health risks. Here's a concise breakdown:

- Kell Positive: Indicates the presence of the K antigen on red blood cells, posing a risk for alloimmune reactions.
- Kell Negative: Absence of the K antigen, reducing the risk of hemolytic disease.
- Heterozygous: Presence of both K and k alleles, indicating partial expression of the K antigen.

These results guide clinical decisions in pregnancy, transfusions, and genetic counseling, ensuring optimal patient care.

Price of test:£889

The lowest price from the last 30 days: £889

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