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Lp-PLA2 (PLAC) Test

Lp-PLA2 (PLAC) Test

The Lp-PLA2 (PLAC) test is a specialized laboratory assessment that measures the activity of the enzyme lipoprotein-associated phospholipase A2 (Lp-PLA2) in the blood. This enzyme is closely linked to atherosclerosis, a condition marked by the accumulation of fatty deposits in the arteries, which can lead to cardiovascular diseases and strokes. Lp-PLA2 is primarily associated with low-density lipoprotein (LDL) particles and plays a role in the oxidative modification of LDL, contributing to plaque formation and destabilization in the arteries. The test involves an enzyme assay using a spectrophotometric method to determine Lp-PLA2 activity, providing a reliable measure of cardiovascular risk. It requires a blood sample, with results reported in nanomoles per minute per milliliter (nmol/min/mL). The Lp-PLA2 test is particularly useful for predicting coronary heart disease risk in patients without prior cardiovascular events, serving as a vascular-specific marker of inflammation.

Price of test:£127

The lowest price from the last 30 days: £127

Awaiting result:

3 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Lp-PLA2 test is a crucial tool for assessing cardiovascular risk by measuring the activity of the enzyme linked to atherosclerosis. Key points include:

- Enzyme Role: Lp-PLA2 is involved in LDL oxidation, contributing to plaque formation.
- Test Method: Conducted via spectrophotometry, measuring enzyme activity in blood samples.
- Specimen Handling: Requires careful handling to prevent hemolysis; stable when refrigerated.
- Result Interpretation: Levels above 225 nmol/min/mL indicate higher cardiovascular risk.
- Clinical Use: Helps predict coronary heart disease risk, independent of other factors.
- Patient Prep: No fasting needed; disclose all medications to ensure accuracy.

Who Should Get Tested

The Lp-PLA2 test is crucial for identifying individuals at risk for cardiovascular diseases. It measures the activity of the enzyme linked to atherosclerosis, aiding in early intervention. Key points include:

- Who Should Be Tested?
- Individuals with no prior cardiovascular events but at risk.
- Patients with elevated LDL levels.
- Those with a family history of heart disease.

- Benefits
- Provides insights into inflammation-related risks.
- Complements traditional lipid tests.

- Considerations
- Inform healthcare providers about medications.
- Ensure proper specimen handling for accurate results.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for assessing cardiovascular risk through the Lp-PLA2 (PLAC) test. This test measures the activity of the enzyme Lp-PLA2, linked to atherosclerosis development. Key points include:

- Result Interpretation: Reported in nmol/min/mL, with a threshold of 225 indicating high cardiovascular risk.
- Clinical Context: Results should be considered alongside other risk factors and clinical evaluations.
- Utility: Useful for predicting coronary heart disease risk, especially in patients without prior cardiovascular events.
- Limitations: Influenced by medications and sample handling; proper procedures are essential for accuracy.

Price of test:£127

The lowest price from the last 30 days: £127

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