Manganese

The manganese blood test is a diagnostic procedure designed to assess manganese levels in the bloodstream. Manganese is vital for numerous bodily functions, including bone development, wound healing, and metabolic processes. However, excessive manganese exposure can lead to toxicity, resulting in various health complications. This test is particularly important for individuals potentially exposed to manganese through industrial environments or those receiving Total Parenteral Nutrition (TPN). A whole blood sample is collected in a royal blue-top (EDTA) tube, with a required volume between 0.6 mL and 2 mL. The sample should remain in its original tube to prevent contamination. The test employs Inductively-Coupled Plasma/Mass Spectrometry (ICP/MS) for precise measurement. Normal manganese levels range from 8.0 to 18.7 μg/L. Elevated levels may indicate exposure, with potential neurological and respiratory effects. Proper specimen handling and awareness of test limitations are crucial for accurate diagnosis and management of manganese-related health concerns.

Price of test:£53

The lowest price from the last 30 days: £53

Awaiting result:

12 hours

Collect material:

Blood

Prepare:

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Purpose of the test

The manganese blood test is essential for assessing manganese exposure and potential toxicity. Key objectives include:

- Identify Exposure: Detect elevated manganese levels, especially in industrial workers or those near pollution sources.
- Monitor Accumulation: Track manganese levels in patients on Total Parenteral Nutrition (TPN).
- Ensure Accurate Results: Use ICP/MS for precise measurement; proper specimen collection and storage are crucial.
- Interpret Results: Elevated levels suggest exposure; consider neurological damage even if levels normalize.
- Acknowledge Limitations: Recognize challenges in detecting long-term, low-dose exposure and interpreting deficiency states.

Who Should Get Tested

The manganese blood test is essential for individuals at risk of manganese exposure. Key groups include:

- Workers in industries like steel, aluminum, textiles, and glass.
- Residents near industrial areas.
- Patients on Total Parenteral Nutrition (TPN).

The test requires a whole blood specimen in a royal blue-top (EDTA) tube. Proper collection and storage are crucial for accuracy. Elevated manganese levels may indicate exposure, but interpretation can be complex due to limitations. Symptoms of toxicity include memory problems and tremors. Discontinuing supplements before testing is advised.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for interpreting the manganese blood test. Here’s a concise guide:

- Normal Range: 8.0 to 18.7 μg/L.
- Elevated Levels: May indicate recent exposure, often linked to industrial environments.
- Deficiency: Poorly defined; levels may be lower in epilepsy.
- High Levels: Can occur in hepatitis or jaundice.
- Considerations: Neurological damage may persist even if levels normalize.
- Limitations: May not detect long-term, low-dose exposure effectively.

Understanding these aspects aids in diagnosing and managing manganese-related health issues.

Price of test:£53

The lowest price from the last 30 days: £53

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