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Methylmalonic acid- Serum

Methylmalonic acid- Serum

The methylmalonic acid (MMA) serum test is a diagnostic procedure used to assess vitamin B12 deficiency and certain metabolic disorders. It measures the concentration of methylmalonic acid in the serum, a byproduct of amino acid metabolism. Normally, methylmalonyl-CoA is converted to succinyl-CoA with the help of vitamin B12. A deficiency in vitamin B12 impairs this conversion, leading to elevated MMA levels. The test involves drawing a blood sample, which is analyzed using liquid chromatography tandem mass spectrometry (LC-MS/MS) to accurately measure MMA levels. Elevated MMA can indicate vitamin B12 deficiency, even when serum B12 levels appear normal, making it useful for detecting subtle deficiencies. The test is often ordered when symptoms like macrocytic anemia or neurological issues are present. While valuable, the MMA test has limitations and is not FDA-approved, though it is performed in CLIA-certified labs. It plays a crucial role in diagnosing conditions like methylmalonic acidemia, especially in newborns.

Price of test:£215

The lowest price from the last 30 days: £215

Awaiting result:

7 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The methylmalonic acid (MMA) serum test is essential for diagnosing vitamin B12 deficiency and metabolic disorders. It measures MMA levels, a byproduct of amino acid breakdown, indicating potential deficiencies.

- Test Procedure: Blood is drawn, serum separated, and analyzed using LC-MS/MS.
- Purpose: Detects elevated MMA levels, signaling vitamin B12 deficiency.
- When Ordered: Symptoms like anemia, neurological issues, or fatigue.
- Interpretation: Elevated MMA suggests deficiency; consider diet and age.
- Limitations: Not FDA-approved; debated necessity for mild deficiencies.

Understanding these aspects aids in effective diagnosis and management.

Who Should Get Tested

The methylmalonic acid (MMA) serum test is crucial for diagnosing vitamin B12 deficiency and metabolic disorders. It measures MMA levels, a byproduct of amino acid breakdown, which accumulate when vitamin B12 is deficient. The test is performed using liquid chromatography tandem mass spectrometry (LC-MS/MS) and is ordered when symptoms like macrocytic anemia or neurological issues appear. Key points include:

- Purpose: Detects elevated MMA levels indicating B12 deficiency.
- Procedure: Blood sample collection and analysis.
- Applications: Diagnoses congenital methylmalonic acidemia and evaluates B12 deficiency.
- Considerations: Not FDA-approved, but valuable in newborn screening.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for effective diagnosis and treatment. The methylmalonic acid (MMA) serum test measures MMA levels to assess vitamin B12 deficiency and metabolic disorders. Key points include:

- Normal Range: 0 to 378 nmol/L.
- Elevated Levels: Suggest vitamin B12 deficiency or methylmalonic acidemia.
- Clinical Use: Identifies subtle deficiencies, aids in diagnosing genetic disorders.
- Considerations: Evaluate alongside diet, age, and nutritional status.
- Limitations: Not FDA-approved; interpret with caution.

Understanding these aspects helps healthcare providers make informed decisions for patient care.

Price of test:£215

The lowest price from the last 30 days: £215

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