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Monospot
The Mumps IgM test is a vital laboratory diagnostic tool designed to detect IgM antibodies against the mumps virus in serum specimens. This test is essential for diagnosing recent or acute mumps infections, especially in individuals who are unvaccinated or have not previously contracted the virus. It serves a dual purpose: aiding in the diagnosis of suspected acute mumps cases and assessing post-vaccination immune responses to determine if protective immunity has developed. The test requires a serum specimen, typically collected in a serum gel or red-top tube, and employs an enzyme immunoassay (EIA) method. This involves incubating diluted serum samples in wells coated with antihuman-IgM monoclonal antibodies, followed by a series of washing, conjugate addition, and substrate reactions to produce a measurable colored product. Results are interpreted based on the presence or absence of IgM antibodies, with positive results indicating recent infection. Despite its limitations, the Mumps IgM test remains crucial for diagnosing mumps and managing outbreaks.
The Mumps IgM test is a vital laboratory diagnostic tool designed to detect IgM antibodies against the mumps virus in serum specimens. This test is essential for diagnosing recent or acute mumps infections, especially in individuals who are unvaccinated or have not previously contracted the virus. It serves a dual purpose: aiding in the diagnosis of suspected acute mumps cases and assessing post-vaccination immune responses to determine if protective immunity has developed. The test requires a serum specimen, typically collected in a serum gel or red-top tube, and employs an enzyme immunoassay (EIA) method. This involves incubating diluted serum samples in wells coated with antihuman-IgM monoclonal antibodies, followed by a series of washing, conjugate addition, and substrate reactions to produce a measurable colored product. Results are interpreted based on the presence or absence of IgM antibodies, with positive results indicating recent infection. Despite its limitations, the Mumps IgM test remains crucial for diagnosing mumps and managing outbreaks.
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The Mumps IgM test is essential for diagnosing recent mumps infections, especially in unvaccinated individuals. It detects IgM antibodies, indicating recent exposure. Key aspects include:
- Purpose: Diagnoses acute mumps and assesses post-vaccine immunity.
- Specimen: Requires 1 mL serum, collected in a serum gel or red-top tube.
- Method: Uses enzyme immunoassay (EIA) involving incubation, washing, and substrate reaction.
- Results: Positive indicates recent infection; negative may require retesting if symptoms persist.
- Clinical Role: Identifies mumps in symptomatic individuals, aiding outbreak control.
- Limitations: Less sensitive than RT-PCR, but crucial for recent infection detection.
The Monospot test is crucial for diagnosing infectious mononucleosis (IM), primarily caused by the Epstein-Barr virus (EBV). It detects heterophile antibodies in the blood, indicating EBV infection. Here's who should be tested:
- Symptomatic Patients: Those with sore throat, fever, malaise, tonsillitis, lymphadenopathy, and fatigue.
- Prolonged Symptoms: Individuals with symptoms persisting beyond typical viral infections.
- Exclusion of Other Illnesses: When other conditions like hepatitis or lupus are suspected.
Despite its utility, the test's sensitivity varies, necessitating further testing if results are negative but symptoms persist.
Understanding test results for the Mumps IgM test involves interpreting the presence or absence of IgM antibodies against the mumps virus. Key points include:
- Positive Result: Indicates recent or acute mumps infection. Consider clinical context due to potential false positives, especially in pregnant women or those with other viral infections.
- Negative Result: Suggests absence of acute infection, but early disease may yield negative results. Re-evaluation is recommended if symptoms persist.
- Clinical Context: Symptoms like fever and parotitis support diagnosis. Consider additional testing for confirmation, especially in vaccinated individuals.
The lowest price from the last 30 days: £46
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