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Myeloperoxidase Abs
The Myeloperoxidase (MPO Abs) antibody test is a vital diagnostic tool for identifying immune-mediated vasculitis, particularly microscopic polyangiitis (MPA). As part of the antineutrophil cytoplasmic antibodies (ANCA) tests, it detects autoantibodies against myeloperoxidase, an enzyme in neutrophils. These autoantibodies, known as MPO-ANCA, are crucial markers for MPA and other ANCA-associated vasculitis forms. The test distinguishes MPA from other vasculitis types like granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Conducted using a semi-quantitative multiplex bead assay, the test involves binding MPO antibodies to fluorescently labeled microspheres. Results are interpreted in conjunction with clinical symptoms and other diagnostic findings. A positive MPO-ANCA result supports an MPA or EGPA diagnosis, while negative results necessitate further testing. The MPO antibody test is essential for diagnosing and monitoring disease activity, guiding treatment decisions, and assessing patient response to therapy.
The Myeloperoxidase (MPO Abs) antibody test is a vital diagnostic tool for identifying immune-mediated vasculitis, particularly microscopic polyangiitis (MPA). As part of the antineutrophil cytoplasmic antibodies (ANCA) tests, it detects autoantibodies against myeloperoxidase, an enzyme in neutrophils. These autoantibodies, known as MPO-ANCA, are crucial markers for MPA and other ANCA-associated vasculitis forms. The test distinguishes MPA from other vasculitis types like granulomatosis with polyangiitis (GPA) and eosinophilic granulomatosis with polyangiitis (EGPA). Conducted using a semi-quantitative multiplex bead assay, the test involves binding MPO antibodies to fluorescently labeled microspheres. Results are interpreted in conjunction with clinical symptoms and other diagnostic findings. A positive MPO-ANCA result supports an MPA or EGPA diagnosis, while negative results necessitate further testing. The MPO antibody test is essential for diagnosing and monitoring disease activity, guiding treatment decisions, and assessing patient response to therapy.
The lowest price from the last 30 days: £109
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The MPO Abs antibody test is crucial for diagnosing immune-mediated vasculitis, especially MPA. It detects MPO-ANCA, distinguishing MPA from other vasculitis types. Key points include:
- Purpose: Identifies MPO-ANCA, aiding in diagnosis and monitoring.
- Methodology: Uses a semi-quantitative multiplex bead assay.
- Interpretation: Positive results suggest MPA or EGPA; context is vital.
- Additional Testing: PR3-ANCA and ANCA by IIF may be needed.
- Specimen: Requires serum, stored appropriately.
- Turnaround: Typically 1-2 days.
- Monitoring: MPO-ANCA reactivity helps assess treatment response.
The Myeloperoxidase (MPO Abs) antibody test is essential for diagnosing immune-mediated vasculitis, especially microscopic polyangiitis (MPA). It detects MPO-ANCA, crucial for distinguishing MPA from other vasculitis forms.
- Purpose: Identifies autoantibodies against myeloperoxidase.
- Clinical Significance: Indicates disease activity and treatment response.
- Methodology: Uses a semi-quantitative multiplex bead assay.
- Interpretation: Positive results suggest MPA or EGPA; context is key.
- Additional Testing: PR3-ANCA and ANCA by IIF may be needed.
- Specimen: Requires serum, stored properly.
- Turnaround: Typically 1-2 days.
Accurate diagnosis combines serological, clinical, and imaging data.
Understanding test results is crucial for accurate diagnosis and management of ANCA-associated vasculitis. Here's a brief guide:
- Positive MPO- Abs: Indicates possible MPA or EGPA; consider clinical symptoms and imaging.
- Negative MPO- Abs Doesn't rule out vasculitis; further testing may be needed.
- Monitoring: MPO-ANCA levels can reflect treatment response but should be considered alongside clinical assessments.
- Additional Tests: PR3- Abs and ANCA by IIF may be necessary for comprehensive evaluation.
- Specimen Handling: Proper serum collection and storage are vital for reliable results.
The lowest price from the last 30 days: £109
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