Phenytoin

The partial thromboplastin time (PTT) test, also known as the activated partial thromboplastin time (aPTT) test, is an essential diagnostic tool for assessing the body's blood clotting ability. By measuring the time it takes for blood to clot after adding specific reagents, the PTT test evaluates the function and quantity of crucial clotting factors, including factors XII, XI, IX, VIII, X, V, II (prothrombin), and I (fibrinogen), as well as prekallikrein and high molecular weight kininogen. These factors are vital for the hemostatic process, which stops bleeding and promotes healing. The test involves a simple blood draw, where the sample is mixed with reagents to activate the coagulation cascade. Normal PTT results range from 25 to 35 seconds, while prolonged times may indicate bleeding disorders, liver disease, or medication effects. The PTT test is often used alongside the prothrombin time (PT) test to diagnose and manage coagulation-related conditions.

Price of test:£63

The lowest price from the last 30 days: £63

Awaiting result:

One day

Collect material:

Blood

Prepare:

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Purpose of the test

The partial thromboplastin time (PTT) test is essential for assessing blood clotting ability. It evaluates the coagulation cascade, focusing on clotting factors like XII, XI, IX, VIII, X, V, II, and I. Here's a brief overview:

- Preparation: Inform healthcare providers about medications, especially blood thinners.
- Blood Draw: Blood is drawn into a tube with anticoagulants.
- Sample Processing: Reagents activate clotting; time to clot is measured.

Normal PTT ranges from 25 to 35 seconds. Abnormal results may indicate bleeding disorders, liver disease, or medication effects.

Who Should Get Tested

Phenytoin is vital for managing seizure disorders, requiring careful monitoring to maintain therapeutic levels and prevent toxicity. Testing is crucial for:

- Therapeutic Level Maintenance: Ensures blood concentration is within 10-20 mcg/mL for effective seizure control.
- Toxicity Diagnosis: Identifies high levels causing symptoms like nystagmus and ataxia.
- Compliance Assessment: Confirms adherence to medication regimen.

No special preparation is needed for the test, which involves a simple blood draw. Regular monitoring helps manage phenytoin's complex pharmacokinetics and interactions, ensuring optimal treatment outcomes.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is essential for interpreting the partial thromboplastin time (PTT) test. This test evaluates the body's ability to form blood clots by measuring the time it takes for blood to clot after reagents are added. Key points include:

- Normal PTT: Indicates proper clotting factor function.
- Prolonged PTT: Suggests issues with clotting factors, possibly due to deficiencies or inhibitors.
- Corrected PTT: Helps identify specific deficiencies or inhibitors.

Abnormal results may indicate bleeding disorders, liver disease, or medication effects, guiding further diagnosis and treatment.

Price of test:£63

The lowest price from the last 30 days: £63

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