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PETH (Phosphatidylethanol)

PETH (Phosphatidylethanol)

The Phosphatidylethanol (PEth) test is a specialized blood test used to measure levels of PEth, an abnormal phospholipid that forms in the presence of ethanol, making it a direct indicator of alcohol consumption. This biomarker is highly specific to alcohol use, as PEth is produced when ethanol interacts with phosphatidylcholine in red blood cells. The test is renowned for its high sensitivity and specificity, effectively detecting moderate to heavy alcohol use with over 90% accuracy. Unlike other alcohol biomarkers, PEth offers a longer detection window, remaining in the blood for two to four weeks, and even longer in chronic drinkers. The test requires a whole blood specimen, typically collected in EDTA tubes, and is analyzed using liquid chromatography-tandem mass spectrometry (LC-MS/MS). PEth levels are interpreted to indicate varying degrees of alcohol consumption, from abstinence to excessive use, making it a valuable tool in clinical settings for monitoring alcohol intake and ensuring abstinence.

Price of test:£207

The lowest price from the last 30 days: £207

Awaiting result:

7 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Phosphatidylethanol (PEth) testing is a crucial tool for assessing recent alcohol consumption. This blood test measures PEth, an abnormal phospholipid formed when ethanol interacts with phosphatidylcholine in red blood cells. Key aspects include:

- Formation: PEth forms specifically in the presence of alcohol, making it a unique biomarker.
- Sensitivity: Highly sensitive and specific, detecting over 90% of moderate to heavy drinkers.
- Detection Window: Offers a longer detection period (2-4 weeks) than other biomarkers.
- Clinical Use: Essential for monitoring patients with alcohol-related conditions or verifying abstinence.

Who Should Get Tested

The Phosphatidylethanol (PEth) test is crucial for identifying individuals who need monitoring for alcohol consumption. Key groups include:

- Patients with a history of alcohol abuse: PEth helps track their progress and abstinence.
- Individuals with liver disease: Monitoring alcohol intake is vital for managing their condition.
- Candidates for liver transplantation: Ensuring abstinence is critical for successful outcomes.
- Pregnant women: PEth offers a safe alternative to urine tests, avoiding associated risks.

This test's high sensitivity and specificity make it indispensable in clinical settings.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Phosphatidylethanol (PEth) test involves interpreting the levels of PEth detected in the blood, which indicate recent alcohol consumption. Key points include:

- Low Levels (<10 µg/L): Suggest abstinence or minimal alcohol use.
- Moderate Levels (10–35 µg/L): Indicate low or occasional drinking.
- High Levels (35–210 µg/L): Reflect social or moderate consumption.
- Very High Levels (>210 µg/L): Signify excessive alcohol intake.

These results help clinicians assess alcohol use, particularly in patients with a history of abuse or liver issues.

Price of test:£207

The lowest price from the last 30 days: £207

AI-Powered Insights and Expert Validation

Advanced AI Interpretation

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At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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