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PETH (Phosphatidylethanol)

PETH (Phosphatidylethanol)

The phenytoin test is a vital diagnostic tool used to measure the concentration of phenytoin, an essential antiepileptic medication, in the blood. Phenytoin, known by its brand name Dilantin, is used to manage seizure disorders by regulating nerve activity and preventing abnormal electrical discharges in the brain. The test ensures that phenytoin levels remain within the therapeutic range of 10 to 20 mcg/mL, crucial for effective seizure control and minimizing toxicity risks. High levels can lead to symptoms like nystagmus, ataxia, and tremors, indicating potential toxicity. The test also assesses patient compliance with the medication regimen. Conducted using a heterogeneous competitive immunoassay method, the test requires a blood sample, with no special preparation needed. Regular monitoring is essential, especially when starting treatment or adjusting other medications, to maintain therapeutic levels and manage potential drug interactions. This test, often accompanied by other blood tests, is integral to optimizing treatment outcomes for individuals with seizure disorders.

Price of test:£180

The lowest price from the last 30 days: £180

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Phenytoin is a vital antiepileptic drug used to manage seizures by reducing electrical conductance in the brain. The phenytoin test measures blood concentration to ensure therapeutic levels, typically between 10 to 20 mcg/mL, are maintained. Key objectives include:

- Therapeutic Level Maintenance: Ensures effective seizure control.
- Toxicity Diagnosis: Identifies high levels causing symptoms like nystagmus and ataxia.
- Compliance Assessment: Checks adherence to medication regimen.

Regular monitoring is crucial for optimal treatment, considering factors like protein binding and drug interactions.

Who Should Get Tested

The Phosphatidylethanol (PEth) test is crucial for identifying individuals who need monitoring for alcohol consumption. Key groups include:

- Patients with a history of alcohol abuse: PEth helps track their progress and abstinence.
- Individuals with liver disease: Monitoring alcohol intake is vital for managing their condition.
- Candidates for liver transplantation: Ensuring abstinence is critical for successful outcomes.
- Pregnant women: PEth offers a safe alternative to urine tests, avoiding associated risks.

This test's high sensitivity and specificity make it indispensable in clinical settings.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding the results of a phenytoin test is crucial for effective seizure management. The test measures phenytoin levels in the blood, expressed in micrograms per milliliter (mcg/mL).

- Therapeutic Range: 10 to 20 mcg/mL, effective for seizure control.
- Toxic Range: Above 20 mcg/mL, may cause adverse effects.
- Critical Value: 30 mcg/mL or higher, indicates severe toxicity.

Interpreting these results helps ensure the medication is within the therapeutic range, minimizing risks and optimizing treatment. Regular monitoring is essential for maintaining effective seizure control.

Price of test:£180

The lowest price from the last 30 days: £180

AI-Powered Insights and Expert Validation

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Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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