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Reticulin Ab's IgG

Reticulin Ab's IgG

The Rabies Antibody test, particularly the Rapid Fluorescent Focus Inhibition Test (RFFIT), is an essential diagnostic tool for assessing the immune response to rabies vaccination. It measures the ability of antibodies in a serum sample to neutralize the rabies virus, ensuring individuals have adequate protection against the disease. This test is crucial for those at high risk of exposure, such as veterinarians and laboratory workers, and for monitoring individuals undergoing post-exposure prophylaxis (PEP). The RFFIT involves preparing and diluting serum samples, mixing them with live rabies virus, and observing the interaction with tissue culture cells under a fluorescent microscope. The endpoint titer, indicating the highest serum dilution that prevents cell infection, is calculated to determine antibody levels. Results are interpreted based on WHO and ACIP guidelines, guiding vaccination decisions and ensuring sufficient protection. Practical considerations include specimen handling and turnaround time, making the RFFIT a vital component of rabies prevention strategies.

Price of test:£94

The lowest price from the last 30 days: £94

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Rabies Antibody test, particularly the RFFIT, is vital for assessing rabies vaccination efficacy. It ensures individuals, especially those at high risk, have developed sufficient antibodies. Key points include:

- Purpose: Evaluates vaccination effectiveness and monitors post-exposure prophylaxis.
- Methodology: Involves serum preparation, serial dilutions, mixing with live virus, cell culture addition, and microscopic observation.
- Interpretation: WHO and ACIP guidelines determine adequate antibody levels.
- Clinical Significance: Guides vaccination decisions, assesses booster needs, and evaluates occupational risk.
- Practical Considerations: Involves specific specimen requirements, handling instructions, and turnaround time.

Who Should Get Tested

The Reticulin Antibody (IgG) test is a serological examination used to detect IgG antibodies against reticulin, a collagen type found in various organs. It is primarily used in diagnosing and monitoring gluten sensitivity-related conditions, such as celiac disease and dermatitis herpetiformis. Although not typically requested alone, it is part of a broader autoantibody screen. Key points include:

- Sample Collection: Serum Separator Tube (SST) is used.
- Diagnostic Cascade: Less frequently used due to lower sensitivity and specificity.
- Primary Tests: Tissue Transglutaminase Antibody (tTG), Deamidated Gliadin Peptide Antibodies (DGP), and Endomysial Antibodies (EMA).
- Monitoring: Antibody tests monitor gluten-free diet effectiveness.
- Asymptomatic Testing: Recommended for close relatives of celiac patients.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for assessing rabies vaccination effectiveness. The Rabies Antibody test, specifically the RFFIT, measures immune response by evaluating antibody levels. Key points include:

- WHO Guidelines: Adequate response is ≥0.5 IU/mL.
- ACIP Guidelines: Complete neutralization at 1:5 dilution is sufficient.

Clinical significance involves:

- Vaccination Status: Confirms protection level.
- Booster Need: Determines if additional doses are required.
- Occupational Risk: Essential for high-risk professions.
- PEP Monitoring: Ensures adequate immune response.

Practical considerations include specimen handling and turnaround time.

Price of test:£94

The lowest price from the last 30 days: £94

AI-Powered Insights and Expert Validation

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Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

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