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Reticulin Ab's IgG

Reticulin Ab's IgG

The Reticulin Antibody (IgG) test is a serological examination used to detect IgG antibodies against reticulin, a collagen type found in various organs. This test is primarily associated with diagnosing and monitoring gluten sensitivity-related conditions, such as celiac disease and dermatitis herpetiformis. Although the presence of anti-reticulin antibodies (ARA) is not clinically significant on its own, it can indicate unsuspected celiac disease in about 50% of cases. Therefore, positive results are often followed by testing for anti-tissue transglutaminase (tTG) antibodies to confirm celiac disease. The test is part of a broader autoantibody screen and involves indirect immunofluorescence using mouse tissue to detect IgG antibodies. While it provides some evidence of gluten sensitivity, it is less specific and sensitive than other tests like the tTG test, which is the primary diagnostic tool for celiac disease. The Reticulin Antibody (IgG) test is less frequently used due to its lower sensitivity and specificity.

Price of test:£108

The lowest price from the last 30 days: £108

Awaiting result:

3 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The Reticulin Antibody (IgG) test is a serological examination used to detect IgG antibodies against reticulin, a collagen type found in various organs. It plays a role in diagnosing and monitoring gluten sensitivity-related conditions, such as celiac disease and dermatitis herpetiformis. Key points include:

- Sample Collection: Uses a Serum Separator Tube (SST) to ensure serum purity.
- Clinical Utility: Less specific and sensitive than other tests like tTG.
- Diagnostic Cascade: Often follows tTG, DGP, and EMA tests.
- Monitoring: Helps evaluate gluten-free diet effectiveness.
- Asymptomatic Testing: Considered for those with a family history of celiac disease.

Who Should Get Tested

The Reticulin Antibody (IgG) test is a serological examination used to detect IgG antibodies against reticulin, a collagen type found in various organs. It is primarily used in diagnosing and monitoring gluten sensitivity-related conditions, such as celiac disease and dermatitis herpetiformis. Although not typically requested alone, it is part of a broader autoantibody screen. Key points include:

- Sample Collection: Serum Separator Tube (SST) is used.
- Diagnostic Cascade: Less frequently used due to lower sensitivity and specificity.
- Primary Tests: Tissue Transglutaminase Antibody (tTG), Deamidated Gliadin Peptide Antibodies (DGP), and Endomysial Antibodies (EMA).
- Monitoring: Antibody tests monitor gluten-free diet effectiveness.
- Asymptomatic Testing: Recommended for close relatives of celiac patients.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for the Reticulin Antibody (IgG) test involves recognizing its role in diagnosing gluten-related disorders. This test detects IgG antibodies against reticulin, aiding in identifying conditions like celiac disease. Key points include:

- Positive Result: Indicates potential gluten sensitivity, warranting further testing.
- Diagnostic Cascade: Often followed by tTG-IgA, DGP-IgA/IgG, and EMA-IgA tests for confirmation.
- Clinical Utility: Less sensitive than other tests, but useful in conjunction with them.
- Monitoring: Helps track treatment effectiveness in diagnosed cases.

Price of test:£108

The lowest price from the last 30 days: £108

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