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Retinol Binding Protein

Retinol Binding Protein

Retinol Binding Protein (RBP) testing is a valuable diagnostic tool primarily used to assess renal tubular injury or dysfunction. RBP is a low-molecular-weight protein crucial for transporting vitamin A from the liver to peripheral tissues, playing a vital role in vision, immune function, and skin health. Clinically, RBP testing helps identify proximal tubule injury by measuring the protein's levels in urine or serum. In urine-based tests, an increase in RBP excretion indicates tubular dysfunction, often linked to conditions like renal tubulointerstitial nephritis or nephrotoxic drug exposure. For serum tests, reduced RBP levels may suggest vitamin A deficiency or undernutrition, while elevated levels can indicate insulin resistance or diabetes risk. Specimen collection involves random urine samples or blood samples for serum analysis, with immunonephelometry and turbidimetric assays commonly used for measurement. RBP testing, often performed alongside other renal function tests, provides critical insights into kidney health and aids in early detection of tubular injury.

Price of test:£75

The lowest price from the last 30 days: £75

Awaiting result:

3 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Retinol Binding Protein (RBP) testing is essential for assessing renal tubular injury or dysfunction. Key points include:

- Clinical Use: Primarily used to detect proximal tubule injury through increased urinary RBP excretion.
- Specimen Collection: Requires a 5 mL random urine sample or serum, with no preservatives.
- Assay Methods:
- Urine: Immunonephelometry detects RBP via light scattering.
- Serum: Turbidimetric assay measures turbidity from RBP-antibody complexes.
- Interpretation: Elevated urinary RBP indicates tubular dysfunction; serum levels reflect vitamin A status and potential metabolic conditions.
- Practical Considerations: Often paired with creatinine tests for comprehensive kidney function assessment.

Who Should Get Tested

Retinol Binding Protein (RBP) testing is essential for assessing renal tubular injury or dysfunction. Key points include:

- Clinical Use: RBP testing helps diagnose kidney issues by detecting increased urinary excretion, indicating proximal tubule injury.

- Specimen Collection: Urine tests require a 5 mL random sample; serum tests need blood samples to analyze separated serum.

- Assay Methods: Urine RBP is measured via immunonephelometry, while serum RBP uses turbidimetric assays.

- Interpretation: Elevated urine RBP suggests kidney dysfunction; serum RBP levels can indicate vitamin A status or metabolic conditions.

Understanding these aspects aids in effective diagnosis and monitoring of kidney health.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for Retinol Binding Protein (RBP) is essential for evaluating kidney health and vitamin A status. Here's a concise guide:

- Elevated Urinary RBP: Indicates proximal tubular dysfunction, possibly due to nephritis or nephrotoxic exposure.
- Reduced Serum RBP: Suggests vitamin A deficiency or undernutrition.
- Elevated Serum RBP: May signal insulin resistance or diabetes risk.
- Reference Values: Urine RBP <190 mcg/g creatinine; serum levels vary with health status.
- Considerations: Ensure urine samples are centrifuged to remove particulates before testing.

Price of test:£75

The lowest price from the last 30 days: £75

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