Reverse T3

The Reverse T3 (rT3) test is a specialized diagnostic tool used to assess thyroid function, particularly in the context of non-thyroidal illnesses. rT3 is a metabolically inactive form of the thyroid hormone triiodothyronine (T3), produced through the deiodination of thyroxine (T4). Under certain conditions, such as stress, illness, or fasting, the body may convert more T4 into rT3 rather than active T3, leading to elevated rT3 levels. This elevation is often observed in conditions like sick euthyroid syndrome, where active T3 levels remain normal despite illness. The test involves a blood sample analyzed using liquid chromatography tandem mass spectrometry (LC-MS/MS) to measure rT3 levels accurately. While not typically part of routine thyroid evaluations, the rT3 test is valuable in specific clinical settings, helping healthcare providers diagnose and manage thyroid-related conditions by offering insights into the body's response to stress and illness.

Price of test:£194

The lowest price from the last 30 days: £194

Awaiting result:

21 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Reverse T3 (rT3) is a metabolically inactive thyroid hormone produced by the deiodination of thyroxine (T4). Its levels can provide insights into thyroid function, especially in non-thyroidal illnesses. Key points include:

- Production: rT3 is formed when T4 is converted in tissues like the liver and kidney.
- Clinical Significance: Elevated rT3 is linked to conditions such as starvation, severe trauma, and hepatic dysfunction.
- Diagnostic Utility: Useful in identifying sick euthyroid syndrome and excluding hypothyroidism in critically ill patients.
- Test Procedure: Involves blood sampling and LC-MS/MS analysis.
- Interpretation: Elevated levels may indicate stress or metabolic imbalances.

Who Should Get Tested

Reverse T3 (rT3) is a metabolically inactive thyroid hormone produced from thyroxine (T4). Its levels can rise in certain conditions, affecting thyroid function assessment. Key points include:

- Production: rT3 is formed by deiodination of T4, especially during stress or illness.
- Clinical Significance: High rT3 levels are seen in conditions like starvation, severe trauma, and hepatic dysfunction.
- Diagnostic Utility: Useful in identifying sick euthyroid syndrome, distinguishing it from hypothyroidism.
- Test Procedure: Involves blood sampling and LC-MS/MS analysis.
- Interpretation: Elevated rT3 may indicate stress or metabolic imbalances.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for reverse T3 (rT3) involves recognizing its role and implications in thyroid function. rT3 is an inactive form of the thyroid hormone, produced when T4 is converted under stress or illness. Key points include:

- Production: rT3 increases during stress, illness, or fasting.
- Clinical Significance: High rT3 levels may indicate sick euthyroid syndrome.
- Diagnostic Utility: Helps differentiate non-thyroidal illness from hypothyroidism.
- Interpretation: Elevated rT3 suggests stress-related conditions; assess alongside other thyroid tests.
- Practical Considerations: Useful in specific clinical scenarios, not routine thyroid evaluations.

Price of test:£194

The lowest price from the last 30 days: £194

AI-Powered Insights and Expert Validation

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