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Single Stranded DNA Ab

Single Stranded DNA Ab

The sickle cell screen is a vital diagnostic test used to identify sickle cell disease (SCD) or sickle cell trait in individuals. SCD is an inherited disorder affecting hemoglobin in red blood cells, causing them to form a sickle shape. This abnormal shape can lead to blockages in small blood vessels, resulting in pain, infections, and organ damage. The test involves a simple blood draw, typically from a vein in the arm, or a heel or finger prick for infants. It detects the presence of hemoglobin S, the mutated form responsible for sickle cell disease. A negative result indicates normal hemoglobin, while a positive result suggests either sickle cell trait or disease. Early diagnosis is crucial for managing SCD, as it allows for timely interventions to prevent complications. Routine newborn screening and targeted testing in high-risk groups are essential for improving health outcomes and quality of life for affected individuals.

Price of test:£94

The lowest price from the last 30 days: £94

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The sickle cell screen is essential for diagnosing sickle cell disease (SCD) or trait, aiding early management. Key points include:

- Purpose: Detects abnormal hemoglobin S, indicating SCD or trait.
- Procedure: Blood sample collected from a vein; less invasive methods for infants.
- Results:
- Negative: No SCD or trait.
- Positive: Indicates trait or disease; further testing needed.
- Importance: Early diagnosis improves outcomes, especially in newborns.
- Who Should Test:
- Newborns
- Immigrants
- Symptomatic individuals
- Those with family history

Who Should Get Tested

The Anti-Single Stranded DNA (ssDNA) antibody test is essential for identifying autoantibodies linked to autoimmune diseases like Systemic Lupus Erythematosus (SLE). It aids in diagnosing and managing these conditions, especially in patients with early or vague symptoms. The test uses an enzyme-linked immunosorbent assay (ELISA) to measure IgG antibodies against ssDNA. Results are categorized as:

- Negative: <68.6 U/mL
- Medium Positive: 68.6-229 U/mL
- Strong Positive: >229 U/mL

This test is crucial for differential diagnosis, monitoring disease activity, and early detection of autoimmune diseases.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is essential for managing sickle cell disease (SCD) or trait. Here's a brief overview:

- Negative Result: Indicates normal hemoglobin; no SCD or trait.
- Positive Result: Suggests sickle cell trait or disease.
- *Trait*: One mutated gene, usually asymptomatic.
- *Disease*: Two mutated genes, leading to symptoms.

A positive result often leads to further testing, like hemoglobin electrophoresis, to confirm the diagnosis. Early detection is vital for effective management and improving health outcomes. Always consult with healthcare providers for personalized advice and treatment plans.

Price of test:£94

The lowest price from the last 30 days: £94

AI-Powered Insights and Expert Validation

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