Spinach IgG

The tacrolimus blood test is a critical tool in managing organ transplant patients, ensuring the drug remains within its narrow therapeutic range to prevent rejection and avoid toxicity. Tacrolimus, derived from *Streptomyces tsulenbaensis*, is a potent immunosuppressant that inhibits T-lymphocyte activation by blocking calcineurin, thus reducing the immune response against transplanted organs. The test requires a whole blood specimen collected in a lavender-top (EDTA) tube, with a preferred volume of 1 mL. It is performed using liquid chromatography/tandem mass spectrometry (LC-MS/MS), a precise method for measuring tacrolimus levels. Maintaining trough levels between 3.0 ng/mL and 8.0 ng/mL is essential for therapeutic efficacy. Drug interactions can significantly alter tacrolimus levels, necessitating careful monitoring and dosage adjustments. By accurately measuring and managing tacrolimus levels, healthcare providers can enhance transplant success rates, minimizing the risks of organ rejection and drug toxicity.

Price of test:£34

The lowest price from the last 30 days: £34

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Tacrolimus, or FK506, is a crucial immunosuppressive drug used to prevent organ rejection in transplant patients. Derived from *Streptomyces tsulenbaensis*, it effectively treats liver and kidney transplant rejection by inhibiting T-lymphocyte activation. Key points include:

- Mechanism: Inhibits calcineurin, reducing T-cell activation.
- Administration: Oral or intravenous, with high plasma protein binding.
- Monitoring: Essential to maintain therapeutic levels (3.0-8.0 ng/mL).
- Specimen: Whole blood in EDTA tube, stored at room temperature.
- Methodology: LC-MS/MS for precise measurement.
- Interactions: Affected by various drugs, requiring careful management.

Who Should Get Tested

The Spinach IgG test is designed to assess immune responses to spinach, aiding in the management of food sensitivities. It involves a blood draw analyzed via ELISA to detect IgG antibodies. However, its clinical utility is not fully established, and it should not be used alone to diagnose food allergies. Key considerations include:

- Clinical Symptoms: Evaluate patient-reported symptoms.
- Other Tests: Consider IgE-mediated allergy tests.
- Dietary Interventions: Implement elimination diets.
- Patient Education: Clarify that IgG presence indicates sensitivity, not allergy.

This test, combined with clinical insights, guides personalized dietary plans.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for tacrolimus is crucial for effective transplant management. Key points include:

- Therapeutic Range: Maintain blood levels between 5 ng/mL and 20 ng/mL to prevent rejection and avoid toxicity.
- Specimen Collection: Use a lavender-top (EDTA) tube; 1 mL of whole blood is preferred.
- Testing Method: LC-MS/MS ensures precise measurement.
- Drug Interactions: Be aware of medications that can alter tacrolimus levels.
- Monitoring: Regularly check blood levels to adjust dosages and ensure therapeutic efficacy.

Price of test:£34

The lowest price from the last 30 days: £34

AI-Powered Insights and Expert Validation

Advanced AI Interpretation

Diagu's AI system represents a breakthrough in medical test analysis, employing state-of-the-art algorithms meticulously trained on a vast spectrum of authoritative medical literature and data. This system intricately analyses laboratory test results, extracting nuanced insights that might elude conventional methods. Our AI delves into complex interrelations between various health markers, offering a comprehensive understanding that supports accurate diagnosis and effective treatment planning. The foundation of our AI's analytical prowess lies in its extensive training, encompassing data from globally recognised medical journals, trusted healthcare databases, and breakthrough scientific studies. This ensures that every analysis is grounded in the latest and most comprehensive medical knowledge.

Expert Doctor Confirmation

While our AI provides deep analytical insights, the human touch remains indispensable. Every AI-generated interpretation is meticulously reviewed by experienced medical professionals, ensuring a harmonious blend of advanced technology and expert clinical judgment. This dual-layer approach guarantees that the insights provided are not only technologically sophisticated but also clinically relevant. Our medical experts ensure that the AI's interpretations align with current medical standards and practices, adding a layer of validation that only seasoned healthcare professionals can provide. This process reinforces the reliability of the test results, offering peace of mind to both patients and healthcare providers.

Language Model and Trusted Sources

At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.

FAQ

Answers to Common Questions

What is GetLabTest.com?

How do I get started with GetLabTest.com?

What diseases can GetLabTest.com detect?

How do I prepare for testing with GetLabTest.com?

Can I speak with a doctor about my results?

Is testing with GetLabTest.com covered by insurance?

How long does it take to receive the test results?

Can I access my test results online?

Is my personal information kept confidential?

What if I have questions or concerns about my test results?