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Tacrolimus FK506

Tacrolimus FK506

The tacrolimus blood test is a critical tool in managing organ transplant patients, ensuring the drug remains within its narrow therapeutic range to prevent rejection and avoid toxicity. Tacrolimus, derived from Streptomyces tsulenbaensis, is a potent immunosuppressant that inhibits T-lymphocyte activation by blocking calcineurin, thus reducing the immune response against transplanted organs. The test requires a whole blood specimen collected in a lavender-top (EDTA) tube, with a preferred volume of 1 mL. It is performed using liquid chromatography/tandem mass spectrometry (LC-MS/MS), a precise method for measuring tacrolimus levels. Maintaining trough levels between 3.0 ng/mL and 8.0 ng/mL is essential for therapeutic efficacy. Drug interactions can significantly alter tacrolimus levels, necessitating careful monitoring and dosage adjustments. By accurately measuring and managing tacrolimus levels, healthcare providers can enhance transplant success rates, minimizing the risks of organ rejection and drug toxicity.

Price of test:£104

The lowest price from the last 30 days: £104

Awaiting result:

14 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Tacrolimus, or FK506, is a crucial immunosuppressive drug used to prevent organ rejection in transplant patients. Derived from Streptomyces tsulenbaensis, it effectively treats liver and kidney transplant rejection by inhibiting T-lymphocyte activation. Key points include:

- Mechanism: Inhibits calcineurin, reducing T-cell activation.
- Administration: Oral or intravenous, with high plasma protein binding.
- Monitoring: Essential to maintain therapeutic levels (3.0-8.0 ng/mL).
- Specimen: Whole blood in EDTA tube, stored at room temperature.
- Methodology: LC-MS/MS for precise measurement.
- Interactions: Affected by various drugs, requiring careful management.

Who Should Get Tested

Tacrolimus is crucial for transplant patients to prevent organ rejection. Testing is essential for:

- Transplant Recipients: Regular monitoring ensures therapeutic levels, minimizing rejection risk.
- Patients with Fluctuating Levels: Adjustments may be needed due to interactions with other drugs.
- Individuals Experiencing Side Effects: Monitoring helps identify toxicity, such as nephrotoxicity or CNS issues.
- Newly Transplanted Patients: Initial high trough levels are critical for early post-transplant care.

Accurate testing and monitoring ensure effective management, improving transplant success.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for tacrolimus is crucial for effective transplant management. Key points include:

- Therapeutic Range: Maintain blood levels between 5 ng/mL and 20 ng/mL to prevent rejection and avoid toxicity.
- Specimen Collection: Use a lavender-top (EDTA) tube; 1 mL of whole blood is preferred.
- Testing Method: LC-MS/MS ensures precise measurement.
- Drug Interactions: Be aware of medications that can alter tacrolimus levels.
- Monitoring: Regularly check blood levels to adjust dosages and ensure therapeutic efficacy.

Price of test:£104

The lowest price from the last 30 days: £104

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