Thyme IgG

The Thiopurine Methyltransferase (TPMT) test is essential for managing patients on thiopurine drugs, which treat conditions like autoimmune diseases and leukemia. TPMT is an enzyme that metabolizes these drugs, preventing toxic buildup in the bone marrow. The test measures TPMT activity in red blood cells to assess the risk of myelosuppression, a dangerous decrease in blood cell production. Results categorize patients into three risk levels: normal, intermediate, and low TPMT activity. Normal activity suggests a low risk of toxicity, while low activity indicates a high risk, necessitating alternative treatments. Intermediate activity requires careful dose adjustments and monitoring. The test involves collecting a whole blood specimen, which must be refrigerated to maintain stability. Methodologies include enzymatic assays and LC/MS-MS. Limitations include potential interference from recent blood transfusions and certain medications. The TPMT test aids in therapeutic drug monitoring and pharmacogenetic profiling, ensuring personalized treatment and minimizing adverse effects.

Price of test:£34

The lowest price from the last 30 days: £34

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Thiopurine Methyltransferase (TPMT) is vital for metabolizing thiopurine drugs, used in treating autoimmune diseases and preventing organ rejection. Testing TPMT activity helps assess myelosuppression risk, crucial for patient safety. Key points include:

- Normal Activity: Low myelosuppression risk; standard dosing is generally safe.
- Low Activity: High risk; avoid thiopurine drugs.
- Intermediate Activity: Requires dose adjustment and monitoring.

Specimen handling involves refrigerated whole blood. Testing uses enzymatic assays and LC/MS-MS. Considerations include avoiding recent transfusions and certain medications. Genetic testing aids personalized treatment.

Who Should Get Tested

The Thyme IgG test is essential for individuals experiencing unexplained symptoms potentially linked to thyme consumption. It helps identify non-allergic immune responses, offering insights into digestive issues or skin rashes. Key candidates for testing include:

- Individuals with persistent digestive discomfort.
- Those with unexplained skin reactions.
- Patients seeking to manage food sensitivities.

The test involves collecting a blood sample, preparing it, and using ELISA to measure IgG antibodies. Results guide dietary choices, aiding in symptom management and preventive care. Understanding IgG levels is crucial for effective treatment strategies.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for TPMT activity is crucial in managing thiopurine therapy effectively. Here's a concise guide:

- Normal Activity: Indicates low risk of myelosuppression; standard dosing is typically safe.
- Low Activity: High risk of severe toxicity; thiopurine drugs should be avoided.
- Intermediate Activity: Requires dose adjustments and close monitoring to manage toxicity risk.

Considerations include avoiding recent blood transfusions and certain medications before testing. Genetic testing can further optimize dosing. This approach ensures safe and effective treatment tailored to individual needs.

Price of test:£34

The lowest price from the last 30 days: £34

AI-Powered Insights and Expert Validation

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