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Thyroid Peroxidase Antibodies

Thyroid Peroxidase Antibodies

The Thyroxine Binding Globulin (TBG) test is a vital diagnostic tool for assessing thyroid function, particularly when total thyroid hormone levels do not align with clinical symptoms. TBG is a high-affinity protein that binds to thyroid hormones thyroxine (T4) and triiodothyronine (T3), regulating their distribution and availability in the body. The thyroid gland adjusts its hormone production based on TBG levels to maintain stable free hormone concentrations. Elevated TBG levels can occur due to pregnancy, oral contraceptives, or estrogen therapy, while decreased levels may result from liver disease, nephrotic syndrome, or certain medications. The TBG test involves a chemiluminescent immunoassay, requiring careful patient preparation, including avoiding biotin supplements before specimen collection. Accurate measurement of TBG helps distinguish between hyperthyroidism and euthyroid states with altered T4 levels, aiding in the precise diagnosis and management of thyroid disorders. This test is particularly useful during pregnancy and in cases involving hormonal therapies or liver conditions.

Price of test:£61

The lowest price from the last 30 days: £61

Awaiting result:

One day

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Thyroxine Binding Globulin (TBG) is essential for regulating thyroid hormones, primarily binding thyroxine (T4) and triiodothyronine (T3). Understanding TBG's role is crucial for accurate thyroid disorder diagnosis. Key points include:

- Function: TBG binds T4 and T3, affecting their availability.
- Regulation: Thyroid adjusts T4/T3 production based on TBG levels.
- Clinical Significance: Elevated TBG in pregnancy; decreased in liver disease.
- Diagnostic Utility: Useful when total hormone levels don't match clinical status.
- Measurement: Involves chemiluminescent immunoassay.
- Specimen Requirements: Serum, specific handling needed.
- Interpretation: Reference values vary by age/gender.

Who Should Get Tested

The thyroid peroxidase (TPO) antibody test is essential for diagnosing and monitoring autoimmune thyroid conditions. It measures antibodies against the TPO enzyme, crucial for thyroid hormone production. Key points include:

- Hashimoto's Thyroiditis: High TPO antibodies indicate this condition, leading to hypothyroidism.
- Graves' Disease: TPO antibodies can also appear, aiding diagnosis of hyperthyroidism.
- Monitoring: Tracks autoimmune activity and treatment effectiveness.

Performed via a simple blood test, results guide healthcare providers in managing thyroid health. Understanding this test is vital for effective treatment and monitoring.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for Thyroxine Binding Globulin (TBG) is crucial for evaluating thyroid function. TBG binds thyroid hormones, affecting their availability. Key points include:

- Elevated TBG Levels: Seen in pregnancy, oral contraceptive use, and estrogen therapy. Total T4 may rise, but free T4 remains stable.
- Decreased TBG Levels: Occur in liver disease, nephrotic syndrome, and certain medications. Total T4 may drop, but free T4 can be normal.
- Diagnostic Utility: Helps differentiate between altered total thyroid hormone levels and actual thyroid dysfunction.

Accurate interpretation aids in managing thyroid disorders effectively.

Price of test:£61

The lowest price from the last 30 days: £61

AI-Powered Insights and Expert Validation

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