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Tissue Transglutaminase IgA


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Tissue transglutaminase IgA detects tissue transglutaminase antibodies is an aid in the diagnosis of certain gluten sensitive enteropathies, such as celiac disease and dermatitis herpetiformis.

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Purpose of the test

The Tissue Transglutaminase IgA (tTG-IgA) test is primarily used to assist doctors in diagnosing celiac disease. Celiac disease is an autoimmune disorder where the immune system mistakenly perceives gluten — a protein found in wheat, barley, rye, and oats — as a foreign threat. As a result, it produces antibodies that target an enzyme in the intestines known as tissue transglutaminase (tTG).

Who Should Get Tested

Doctors might recommend the tTG-IgA test for children displaying symptoms consistent with celiac disease. These symptoms can include poor growth, abdominal pain, constipation, vomiting, diarrhea, or skin rashes. Additionally, the test might be suggested for children with conditions that increase the likelihood of celiac disease, such as type 1 diabetes, thyroid disease, or if they have a family member diagnosed with celiac disease.

Preparing for the Test
Depending on the type of cholesterol test, you may be required to fast for 9 to 12 hours before the test. This means avoiding all food and drinks except water. Fasting is usually required for a lipid panel, which measures LDL and HDL cholesterol, and triglycerides.
Inform your healthcare provider about any medications you are currently taking, including over-the-counter medications and supplements, as they can affect your test results.
Avoid alcohol consumption for at least 24 hours before the test, as alcohol can raise triglyceride levels.
Avoid heavy exercise for 24 hours before the test, as this can also affect cholesterol and triglyceride levels.
Avoid smoking or using any nicotine products for at least 30 minutes before the test, as they can temporarily increase cholesterol levels.
Follow instructions
Follow any specific instructions provided by your healthcare provider, such as the time of day to take the test or any dietary restrictions.
Interpreting Test Results

A positive result from the tTG-IgA test can indicate the presence of celiac disease, as it signifies the immune system's production of antibodies against tissue transglutaminase due to gluten consumption. However, it's essential to consult with a healthcare professional to interpret the results accurately and determine the best course of action or any further testing if needed.

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