Transferrin

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Transferrin (Tf), a glycoprotein of 79.5 kDa, contains two homologous iron-binding domains, each of which binds one Fe3+. Transferrin transports iron in the blood stream and delivers it to various tissues, after binding to a specific receptor (TfR) on the cell surface. After binding to specific cell surface receptors, the ligands follow two different pathways:

1. some are degraded within the cells after dissociation from the receptors and

2. others are not degraded but exocytosed intact into the extracellular space.

This is the fate of Tf that leaves the iron within the cells in endocytosed vesicles and, as apotransferrin, comes back to the membrane.

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Awaiting result:

One day

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Collect material:

Blood

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Prepare:

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Purpose of the test

The Transferrin test measures the amount of the protein transferrin in the blood. Transferrin is produced by the liver and plays a crucial role in transporting iron throughout the body. When the body's iron stores are low, the liver produces more transferrin to increase iron availability in the blood. This test provides insights into the body's iron supply and can help diagnose conditions affecting it.

Who Should Get Tested

Individuals displaying symptoms of anemia, especially iron-deficiency anemia, may need this test. Symptoms can include extreme fatigue, pale skin, dizziness, irritability, headaches, and shortness of breath. Anemia can arise from blood loss, poor iron absorption from food, or during pregnancy.

Preparing for the Test
Fasting
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Depending on the type of cholesterol test, you may be required to fast for 9 to 12 hours before the test. This means avoiding all food and drinks except water. Fasting is usually required for a lipid panel, which measures LDL and HDL cholesterol, and triglycerides.
Medications
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Inform your healthcare provider about any medications you are currently taking, including over-the-counter medications and supplements, as they can affect your test results.
Alcohol
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Avoid alcohol consumption for at least 24 hours before the test, as alcohol can raise triglyceride levels.
Exercise
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Avoid heavy exercise for 24 hours before the test, as this can also affect cholesterol and triglyceride levels.
Smoking
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Avoid smoking or using any nicotine products for at least 30 minutes before the test, as they can temporarily increase cholesterol levels.
Follow instructions
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Follow any specific instructions provided by your healthcare provider, such as the time of day to take the test or any dietary restrictions.
Interpreting Test Results

Test results are provided in milligrams per deciliter (mg/dL) for transferrin and micrograms per deciliter (mcg/dL) for total iron-binding capacity (TIBC). Normal transferrin values range from 215 to 380 mg/dL. Elevated levels might indicate iron-deficiency anemia, while lower levels could suggest liver disease or other conditions. TIBC values between 250 to 450 mcg/dL are considered normal. Another metric, transferrin saturation, assesses the proportion of transferrin binding sites occupied by iron. Normal values range from 15% to 50%. Abnormal values in these tests can help diagnose various health conditions related to iron metabolism.

AI-Powered Insights and Expert Validation
Advanced AI Interpretation
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Expert Doctor Confirmation
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Language Model and Trusted Sources
At the core of Diagu's AI system is an advanced language model, engineered to transform complex medical data into clear, comprehensible, and informative descriptions. This model is adept at articulating detailed test analyses in a way that is accessible to both healthcare professionals and patients. The model's development involved the meticulous processing of high-quality sources, including reputable medical websites, renowned medical textbooks, and peer-reviewed research papers. This ensures that the language used in test descriptions is not only accurate and informative but also up-to-date with the latest medical findings and trends. By leveraging this rich tapestry of trusted sources, our AI system provides a deeper understanding of each test, fostering informed decision-making and enhanced patient care.