Transferrin Saturation
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Iron (transferrin) % saturation is calculated by an equation using plasma iron and transferrin. TIBC is a calculated parameter derived from the transferrin plasma concentration. In hereditary hemochromatosis, serum iron is usually > 150 μg/dL and iron (transferrin) saturation is greater than 60%.
Iron (transferrin) % saturation is calculated by an equation using plasma iron and transferrin. TIBC is a calculated parameter derived from the transferrin plasma concentration. In hereditary hemochromatosis, serum iron is usually > 150 μg/dL and iron (transferrin) saturation is greater than 60%.
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Purpose of the test
The Transferrin Saturation test determines an individual's iron status by using the ratio of serum iron concentration to the total iron binding capacity (TIBC) as a percentage. This test provides insights into how much iron in the blood is bound to transferrin, a glycoprotein responsible for transporting iron around the body. The percentage of transferrin saturation can increase or decrease based on the body's iron status, making it a valuable metric for assessing iron-related conditions.
Who Should Get Tested
Individuals displaying symptoms of iron deficiency anaemia or haemochromatosis (iron overload) should consider this test. Symptoms of iron deficiency include tiredness, pale skin, shortness of breath, and heart palpitations. On the other hand, haemochromatosis can manifest as fatigue, joint pain, stomach pain, liver damage, and other related symptoms.
Blood Test Preparation Guidelines
Time of day
It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.
Fasting
It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.
Stay hydrated
Drinking water prior to testing can help with sample collection.
Other factors
Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.
Medications and supplements:
Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.
Biotin supplements:
High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.
Interpreting Test Results
The test results will show the percentage of transferrin saturation, indicating how much serum iron is bound to transferrin. A low percentage often signifies iron deficiency, while a high percentage can confirm conditions like haemochromatosis. Understanding these results can help diagnose various health conditions related to iron metabolism and guide appropriate interventions or treatments.
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