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Tumor Necrosis Factor -alpha

Tumor Necrosis Factor -alpha

The Tumor Necrosis Factor-alpha (TNF-alpha) test is a crucial diagnostic tool that measures the levels of TNF-alpha, a cytokine integral to the body's immune response, particularly in inflammation regulation, cell death, and immune homeostasis. This test provides insights into various physiological and pathological processes by evaluating the body's inflammatory response. Elevated TNF-alpha levels are often linked to systemic infections, especially those caused by gram-negative bacteria, and chronic inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease. The test also aids in assessing infection severity and predicting outcomes in conditions such as sepsis and severe COVID-19. Blood samples, either plasma or serum, are required for the test, with specific handling and freezing protocols to ensure sample stability. Methodologies like electrochemiluminescence (ECL) and enzyme-linked immunosorbent assay (ELISA) are employed for measurement. While the test is invaluable in clinical and research settings, it requires careful interpretation and consideration of limitations, including sample handling and potential assay interference.

Price of test:£198

The lowest price from the last 30 days: £198

Awaiting result:

14 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The measurement of Tumor Necrosis Factor-alpha (TNF-alpha) is crucial for evaluating the body's inflammatory response and immune regulation. This test provides insights into various physiological and pathological processes.

- Purpose: Assess inflammation, infections, and autoimmune disorders.
- Specimen: Blood sample; plasma or serum.
- Methodology: Electrochemiluminescence (ECL) or ELISA.
- Interpretation: High levels indicate active inflammation; low levels suggest immunosuppression.
- Applications: Diagnosis, management, and research in immune and inflammatory disorders.
- Limitations: Requires standardized methods; potential interference from treatments.

Who Should Get Tested

Testing for TNF-alpha levels is crucial for individuals with symptoms or conditions linked to inflammation. Key groups who may benefit from this test include:

- Patients with chronic inflammatory disorders like rheumatoid arthritis or inflammatory bowel disease.
- Individuals experiencing severe infections, particularly those caused by gram-negative bacteria.
- Patients with autoimmune diseases or suspected immune dysregulation.
- Individuals with severe COVID-19 or sepsis, to assess infection severity and predict outcomes.
- Those undergoing treatment with biologics targeting TNF-alpha, to monitor therapy effectiveness.

Understanding TNF-alpha levels aids in diagnosis and management of these conditions.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for TNF-alpha levels is crucial for evaluating inflammatory responses. Here's a concise guide:

- Elevated Levels: Indicate active inflammation, often linked to infections, autoimmune diseases, or cancer. High levels in sepsis can lead to septic shock.

- Low Levels: May suggest immunosuppression or absence of inflammation, but must be interpreted in clinical context.

- Clinical Context: Always consider patient history and symptoms for accurate interpretation.

- Limitations: Variability in assay methods and sample handling can affect results. Ensure proper standardization for reliability.

Price of test:£198

The lowest price from the last 30 days: £198

AI-Powered Insights and Expert Validation

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