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Vitamin B1 (Thiamine)
The Thiamine Diphosphate (TDP) test is a vital diagnostic tool for assessing thiamine (Vitamin B1) deficiency, crucial for carbohydrate metabolism, brain function, and nerve health. This test measures TDP levels in whole blood, providing insights into potential deficiencies that can lead to severe symptoms like behavioral changes, gait disturbances, and encephalopathy. It is particularly recommended for individuals with clinical symptoms of deficiency, questionable nutritional status, or those belonging to high-risk groups such as alcoholics, dialysis patients, and individuals with malabsorption issues. However, recent vitamin supplementation or non-fasting status can affect results. The test employs liquid chromatography tandem mass spectrometry (LC-MS/MS) for precise measurement, requiring a whole blood sample collected in an EDTA tube, protected from light, and stored at -20°C. While the test indicates potential deficiency, it is not confirmatory, necessitating further clinical evaluation. Turnaround time is typically 4-6 days, aiding timely diagnosis and management of thiamine deficiency.
The Thiamine Diphosphate (TDP) test is a vital diagnostic tool for assessing thiamine (Vitamin B1) deficiency, crucial for carbohydrate metabolism, brain function, and nerve health. This test measures TDP levels in whole blood, providing insights into potential deficiencies that can lead to severe symptoms like behavioral changes, gait disturbances, and encephalopathy. It is particularly recommended for individuals with clinical symptoms of deficiency, questionable nutritional status, or those belonging to high-risk groups such as alcoholics, dialysis patients, and individuals with malabsorption issues. However, recent vitamin supplementation or non-fasting status can affect results. The test employs liquid chromatography tandem mass spectrometry (LC-MS/MS) for precise measurement, requiring a whole blood sample collected in an EDTA tube, protected from light, and stored at -20°C. While the test indicates potential deficiency, it is not confirmatory, necessitating further clinical evaluation. Turnaround time is typically 4-6 days, aiding timely diagnosis and management of thiamine deficiency.
The lowest price from the last 30 days: £105
Awaiting result:
One day
Collect material:
Blood
Prepare:
Vitamin B1, or thiamine, is vital for carbohydrate metabolism, brain function, and nerve myelination. The test measures thiamine diphosphate (TDP) in blood to assess deficiency, useful for identifying at-risk individuals.
- Order Test If:
- Symptoms like behavioral changes, eye signs, gait issues, delirium, encephalopathy.
- Questionable nutritional status, especially with insulin use.
- High-risk groups: breastfed infants of deficient mothers, low thiamine diet, alcoholics, dialysis patients, chronic diarrhea, malabsorption diseases, HIV/AIDS, post-bariatric surgery, high-dose diuretics, parenteral nutrition.
- Avoid Test If:
- Clinical diagnosis is evident.
- Recent vitamin supplementation.
- Interpretation:
- Compare TDP levels to reference interval.
- Low levels suggest deficiency but need further assessment for cause.
- Factors Affecting Results:
- Non-fasting, recent supplementation, light exposure.
- Methodology:
- Uses LC-MS/MS for precise TDP measurement in whole blood.
- Specimen Requirements:
- Whole blood in EDTA tube, frozen within 24 hours, stored at -20°C.
- Patient Preparation:
- Fast 12-14 hours, avoid supplements 12 hours prior.
Understanding these aspects aids in diagnosing and managing thiamine deficiency effectively.
The thiamine diphosphate (TDP) test is essential for assessing thiamine deficiency, crucial for carbohydrate metabolism and nerve function. It measures TDP levels in whole blood, identifying those at risk of deficiency, which can cause symptoms like behavioral changes and delirium.
When to Order the Test:
- Clinical Symptoms: Behavioral changes, eye signs, gait disturbances.
- Nutritional Concerns: Patients with questionable nutritional status.
- Special Populations: Alcoholics, dialysis patients, and those with malabsorption issues.
When Not to Order:
- Clinical Diagnosis: Based on response to vitamin B1 supplementation.
- Recent Supplementation: Can affect results.
Understanding test results for thiamine diphosphate (TDP) levels is crucial in assessing vitamin B1 deficiency. This test measures TDP concentration in whole blood, helping identify individuals at risk of deficiency, which can lead to serious symptoms like behavioral changes and encephalopathy.
Key points:
- Interpretation: Compare TDP levels to reference intervals; low levels suggest deficiency.
- Non-Diagnostic: Results indicate potential deficiency but require further clinical evaluation.
- Influencing Factors: Non-fasting, recent supplementation, and light exposure can affect results.
- Special Populations: Consider higher risk groups like alcoholics and those with malabsorption issues.
The lowest price from the last 30 days: £105
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