Vitamin K

The vitamin K test is a crucial laboratory assessment used to evaluate the nutritional status of this essential fat-soluble vitamin, which is vital for blood clotting and bone metabolism. The test primarily measures phylloquinone (K1) levels in serum using advanced techniques like high-performance liquid chromatography (HPLC) or liquid chromatography/tandem mass spectrometry (LC/MS-MS). Patients must fast for 12 hours and avoid alcohol for 24 hours before the test to ensure accurate results. Blood samples are collected via venipuncture and must be protected from light to prevent degradation of vitamin K. The preferred specimen is serum or plasma, stored in specific conditions to maintain stability. Results are interpreted based on a reference range of 0.10 to 2.20 ng/mL, with low levels indicating potential deficiency. This test is particularly beneficial for patients with suspected bleeding disorders, malabsorption issues, or those on medications affecting vitamin K absorption. Despite its utility, the test has limitations, such as potential false positives due to recent dietary intake.

Price of test:£149

The lowest price from the last 30 days: £149

Awaiting result:

14 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

Testing for vitamin K levels is essential for evaluating nutritional status and identifying deficiencies. Key points include:

- Purpose: Assess vitamin K's role in blood clotting and bone metabolism.
- Preparation: Fast for 12 hours; avoid alcohol for 24 hours.
- Specimen: Serum or plasma, protected from light.
- Collection: Venipuncture; mix samples gently.
- Storage: Refrigerate or freeze; protect from light.
- Methodology: HPLC or LC/MS-MS for phylloquinone measurement.
- Interpretation: Low levels indicate deficiency; high levels may reflect recent intake.

Who Should Get Tested

Testing for vitamin K levels is crucial for evaluating nutritional status and diagnosing deficiencies. Individuals who may need testing include:

- Those with suspected bleeding disorders
- Individuals on restricted diets
- Patients with malabsorption conditions (e.g., celiac disease)
- People taking medications affecting vitamin K absorption

Preparation involves fasting for 12 hours and avoiding alcohol for 24 hours. Blood samples should be protected from light and stored properly. Testing methods like HPLC or LC/MS-MS measure vitamin K1 levels, with results indicating nutritional status. Limitations include potential false positives from recent dietary intake.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results for vitamin K levels is crucial for evaluating nutritional status and potential deficiencies. Here’s a concise guide:

- Purpose: Assess vitamin K's role in blood clotting and bone metabolism.
- Preparation: Fast for 12 hours; avoid alcohol for 24 hours.
- Specimen: Serum or plasma, protected from light.
- Collection: Use venipuncture; mix samples gently.
- Storage: Refrigerate or freeze to maintain stability.
- Methodology: HPLC or LC/MS-MS for precise measurement.
- Interpretation: Low levels indicate deficiency; high levels may result from diet or supplements.

Price of test:£149

The lowest price from the last 30 days: £149

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