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Voltage Gated Potassium Channel Ab's

Voltage Gated Potassium Channel Ab's

The Voltage Gated Potassium Channel (VGKC) antibodies test is a specialized laboratory assay used to detect autoantibodies targeting the VGKC complex, which are linked to various neurological disorders. These disorders include acquired neuromyotonia, characterized by muscle stiffness and spasms; Morvan’s syndrome, which combines neuromyotonia with symptoms like excessive sweating and insomnia; and limbic encephalitis, an inflammatory condition affecting memory and cognition. The test is crucial for diagnosing these conditions, as it helps differentiate between various neurological disorders and guides treatment strategies. It involves analyzing serum samples for autoantibodies using methods like radioimmunoassay. Results are interpreted based on antibody concentration, with further tests available to identify specific antibodies like LGI1 or CASPR2. While the VGKC antibody test is a valuable diagnostic tool, it should be used alongside other clinical assessments due to its limitations. Proper sample handling and timely processing are essential for accurate results, with a typical turnaround time of 1 to 8 days.

Price of test:£267

The lowest price from the last 30 days: £267

Awaiting result:

28 days

Collect material:

Blood

Prepare:

Learn more

Purpose of the test

The VGKC antibodies test aims to detect autoantibodies linked to neurological conditions. Key objectives include:

- Diagnosis: Identify conditions like acquired neuromyotonia, Morvan’s syndrome, and limbic encephalitis.
- Management: Guide treatment strategies, such as immunomodulatory therapies.
- Differentiation: Distinguish between various neurological disorders.
- Confirmation: Use alongside other diagnostic procedures for accurate results.
- Sample Handling: Ensure proper collection and storage for reliable outcomes.

This test is crucial for understanding and managing complex neuromuscular and cognitive impairments.

Who Should Get Tested

The VGKC antibodies test is essential for diagnosing neurological conditions like acquired neuromyotonia, Morvan’s syndrome, and limbic encephalitis. These conditions can cause severe neuromuscular and cognitive impairments. Key points include:

- Acquired Neuromyotonia: Persistent muscle stiffness and spasms.
- Morvan’s Syndrome: Combines neuromyotonia with symptoms like hyperhidrosis and insomnia.
- Limbic Encephalitis: Involves memory loss and seizures.

The test detects autoantibodies in serum, guiding treatment with immunomodulatory therapies. Proper sample handling and interpretation are crucial for accurate diagnosis and management.

Blood Test Preparation Guidelines

Time of day

It is recommended to schedule your appointment for blood tests in the morning hours between 7:00-10:00.

Fasting

It is recommended to fast for approximately 12 hours before blood sampling. The last meal of the previous day should ideally be consumed around 6:00 p.m. On the day before the test, avoid heavy and fatty meals as well as alcohol.

Stay hydrated

Drinking water prior to testing can help with sample collection.

Other factors

Tests should not be performed after a sleepless night or intense physical activity. It is recommended to avoid exercise and stress immediately before blood collection and to not smoke. A short rest is recommended.

Medications and supplements:

Blood samples should be collected before the morning dose. Some drugs can interfere with test results. Consult with your doctor whether you can delay your dose because of lab tests.

Biotin supplements:

High doses of biotin supplements can affect test results, causing false elevation or reduction. It's recommended to avoid taking biotin for at least 72 hours before blood collection. If you are taking biotin, inform the personnel collecting the blood so that they can provide specific instructions.

Interpreting Test Results

Understanding test results is crucial for effective diagnosis and management. The VGKC antibodies test identifies autoantibodies linked to neurological conditions. Here's how to interpret the results:

- Negative: Less than 69 pmol/L
- Equivocal: 70 to 130 pmol/L
- Positive: Greater than 130 pmol/L

Positive or indeterminate results may require further testing to pinpoint specific autoantibodies like LGI1 or CASPR2. These insights guide treatment decisions, such as immunomodulatory therapies, to alleviate symptoms. Always consider results alongside clinical history and other tests for accurate diagnosis.

Price of test:£267

The lowest price from the last 30 days: £267

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